2. The Bridge from Patient to Scientist

3. Comparison: BioBank and Cancer Registry Data Source Distinct Patients Percent BioBank5113100% Cancer Registry460790.1% To be Reviewed5069.9%

4. Comparison: Gynecology Cases Added Value 66 Minor Differences 34 Complete Match 10 Total Cases in BioBank & Registry 110

5. BioBank or Biorepository What is a BioBank? a resource that collects, stores, processes and distributes human specimens such as tissue, body fluids, and blood to scientists for a various research projects. UHN BioBank Established in 2001 Currently, stores samples from over 20,000 patients, equaling over 60,000 high quality biospecimens. Current computer system: Oracle back Access front end Storage location Patient demographics and consent Pathology diagnosis (text data fields)

6. Princess Margaret Hospital Cancer Registry Princess Margaret Hospital 0pened in 1958 in Toronto, Ontario Hospital Cancer Registry was in operation from the beginning In 1998 became part of the University Health Network along with 2 acute care facilities that perform primary cancer surgery Over 12,000 new cancer cases per year. Collect standard registry information according to NAACCR standards Demographics Disease Stage Treatment Follow-Up

7. Linkage BioBank Cancer Registry Clinically annotated biospecimens

8. POP-Cure Colon Cancer Study The goal of this study is to identify and validate new molecular biomarkers and potential therapeutic targets through complementary genomic and functional genomic approaches coupled with molecular pathology and a large retrospective and prospective clinical biobank. Stage II and III colon adenocarcinoma

9. POP-Cure-Project Flow Cancer Registry Identified Colon Cases for 2001 onwards to match time period of the bank Biobank pulled slides for the cases. Insufficient cases Cancer Registry to go back and identify back to 1995 (when slides and blocks available) Identify 500 cases for Tissue Micro Array (TMA)

10. POP-Cure Data Required Additional Data Date of RecurrenceSite of Recurrence Data from Cancer Registry TreatmentDate of DiagnosisLast Date and Status Pathology Data-Selection Criteria Location within the ColonAdenocarcinomaStage II, III

11. Acknowledgements

12. Advantages Biobank Ability to search by cancer site, histology, stage, treatment given Limited Clinical Follow-up Cancer Registry Identify missed cases Additional project driven follow-up

13. Comparison of Ovarian Cases Ovarian Bank Biospecimens with pathology annotation Limited treatment & follow-up data Cancer Registry Given MRN to cross check in registry Provided diagnosis, stage, treatment & follow-up Comparison Pathology Correlation (site/morphology) Clinical data where available

14. Problem UHN BioBank Patient consent Surgical number Cancer Registry Diagnosis Stage Site

15. Thank you