1. Cure4Kids – Global Online Education, Collaboration, and Emerging Technologies A. Patel, J. Knight, R. O’Brien, A. Shuler, B. Schaeffer, Y. Quintana, and R. Ribeiro International Outreach Program St. Jude Children's Research Hospital

2. Safety Safety via software design Safety training via online collaboration platforms.

3. St. Jude Children’s Research Hospital A Hospital Without Walls

4. IOP Mission: To improve survival rates of children with cancer and other catastrophic diseases around the world, through sharing of knowledge, expertise, and technology.

6. 35 users – Oct 2002

7. 17,000+ users, 165 countries

8. Seminars

9. Cure4Kids Research Seminars

10. Cure4Kids Global Collaborations St. Jude, USA Rabat, MoroccoCasablanca, Morocco Cure4Kids Live Meetings Cure4Kids Live meeting between Morocco and St. Jude staff

11. Courses 20+ courses | Instructor led + self paced | Moodle use in future

12. Oncopedia 150+ cases/images | 10+ chapters | Editorial board review | Polls/Quizes/Wikis

13. Oncopedia Case

14. Cure4Kids for Kids Education materials for children: Print & Web format Community Outreach Program

15. POND Pediatric Oncology Network Database

16. POND

17. Sites in POND POND supports virtual areas called “sites”. 30+ active sites currently. Patient data is private among sites. – Unless…

18. Sharing / Security …Unless a site administrator initiates a share. Even if data is shared, sensitive fields like name, birth date are blocked.

19. Patient Summary

20. Quickforms Overview: – 1700 clinical data fields – 30+ active sites Purpose: – Not everyone uses the same workflow. Solution: – Allow them to customize their forms.

21. Designing a Quickform

22. This is how it looks:

23. POND Survival Curve AML by Site in 4 AHOPCA Countries

24. SAFETY PARADIGM As implemented in POND

25. Menus vs. Text Race field in POND

26. Race field Text inputMenu input Language implications

27. Menus vs. Text Use of international reporting standards whenever possible. CTCAE v3: Toxicity Grading

28. Toxicity CTCAE v3 in POND

29. Protocols Design a treatment plan in POND – Defining drugs and dosage information and date/time Apply the treatment plan to the patient (roadmap) – Calculates dosage automatically based on current patient information

30. Dosage Calculations

31. Cure4Kids Global Collaborations St. Jude, USA Rabat, MoroccoCasablanca, Morocco Cure4Kids Live Meetings Cure4Kids Live meeting between Morocco and St. Jude staff Data manager training

32. SYSTEM ARCHITECTURE

33. User Experience Individual interfacesWidget libraryMessaging system Common Framework Database abstraction Authentication support Support functions Template system Common Libraries PEAR libraries DB and XML libraries PECL extensions CURL and SMTP email Javascript libraries Prototype and Scriptaculous Platform Debian LinuxApache httpdMySQLPHP Cure4Kids Architecture System Architecture

34. Common Platform

35. POND: Data Structure Architecture All data fields are “described” fully in a well defined schema. Several engines then use the schema to perform various tasks: – Automatic report generation – Form generation – Data validation + messaging.

36. Forms All the code above generated automatically by the form engine (using widget library)

37. Widget Library Allows html agnostic reproduction of forms.

38. Multilingual interface

39. Lessons Safety guidelines implemented through software can work. Rapid prototyping in real life. Release often. Better feedback cycle. Open source tools Free Friendly communities with robust support. Secure Common Libraries PEAR librariesPECL extensionsJavascript libraries Platform Debian LinuxApache httpdMySQLPHP

40. Questions? Aman Patel Sr. Software Architect International Outreach Program St. Jude Children’s Research Hospital aman.patel@stjude.org http://www.cure4kids.org