1. Date of download: 7/11/2016 From: The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods Ann Intern Med. 1994;120(7):552-558. doi:10.7326/0003-4819-120-7-199404010-00004 Plots of Coumatrak monitor data as a function of plasma prothrombin time data.A.rnB.INRsrnplot of Coumatrak monitor prothrombin time ratios (PTRs) as a function of plasma prothrombin time ratios obtained with a high sensitivity thromboplastin (Dade IS). The Equation for the linear regression line is Y = 0.36X + 0.88, = 0.87, = 100. A plot of Coumatrak monitor international normalized ratios ( ) as a function of plasma prothrombin time INRs obtained with Dade IS thromboplastin. The Equation for the linear regression line is Y = 0.84X + 0.62, = 0.90, = 100. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 7/11/2016 From: The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods Ann Intern Med. 1994;120(7):552-558. doi:10.7326/0003-4819-120-7-199404010-00004 Linear regression lines derived from prothrombin time ratios and from international normalized ratios.A.B.[6]The linear regression lines obtained by plotting prothrombin time ratios (PTRs) determined with five thromboplastins and with the Coumatrak monitor as a function of prothrombin time ratios obtained with Dade IS. The linear regression lines obtained after converting the data of panel A to international normalized ratios [INRs]. In both panels A and B, the thromboplastins are numbered as follows: 1) Ortho; ISI, 2.30; 2) Dade C; ISI, 2.88; 3) Dade C-plus; ISI, 2.03; 4) Excel-S; ISI, 1.34; 5) Excel; ISI, 1.99 or 2.04 for two lots used. Line 6 is the regression line for the Coumatrak monitor data. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 7/11/2016 From: The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods Ann Intern Med. 1994;120(7):552-558. doi:10.7326/0003-4819-120-7-199404010-00004 Plots of plasma prothrombin times expressed as 1/INR as a function of percent prothrombin-proconvertin (P&P) activity.A.B.A primary plot of 1/INR values obtained with Dade IS as a function of values for percent P&P activity. The linear regression lines of 1/INR values obtained from plasma prothrombin times done with each of the six thromboplastins plotted as a function of percent P&P activity. INR = international normalized ratio. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 7/11/2016 From: The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods Ann Intern Med. 1994;120(7):552-558. doi:10.7326/0003-4819-120-7-199404010-00004 Plots of plasma prothrombin times expressed as 1/INR as a function of plasma native prothrombin antigen (NPA) levels.A.B.A primary plot of 1/INR values obtained with Dade IS as a function of values for native prothrombin antigen. The linear regression lines of 1/INR values obtained from plasma prothrombin times done with each of the six thromboplastins plotted as a function of native prothrombin antigen. INR = international normalized ratio. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 7/11/2016 From: The International Normalized Ratio (INR) for Monitoring Warfarin Therapy: Reliability and Relation to Other Monitoring Methods Ann Intern Med. 1994;120(7):552-558. doi:10.7326/0003-4819-120-7-199404010-00004 Plots of plasma prothrombin times expressed as 1/INR as a function of percent specific plasma prothrombin activity.A.B.A primary plot of 1/INR values obtained with Dade IS as a function of values for specific plasma prothrombin activity. The linear regression lines of 1/INR values obtained from plasma prothrombin times done with each of the six thromboplastins plotted as a function of specific plasma prothrombin activity. INR = international normalized ratio. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians