1. Frodo Links Dishevelled to the p120-Catenin/Kaiso Pathway: Distinct Catenin Subfamilies Promote Wnt Signals Park et al. Dev Cell. (2006)

2. McCrea et al. Biochim Biophys Acta. (2006) Linear structural representation of catenin family proteins

3. McCrea et al. Biochim Biophys Acta. (2006) Signaling pathways and interactions involving p120-catenin A)Cadherin stability B)Phosphorylation C)Transcription D)Small G protein E)Inflammation / proliferation

4. van Roy et al. Nat Rev Cancer. (2005) Molecular complexes of Kaiso and LEF/TCF with armadillo proteins in the nucleus BTB/POZ-ZF : Broad complex, Tramtrack, Bric a brac(BTB) or poxvirus and zinc finger (POZ)-ZF. Implicated in tumorigenesis. Kaiso : Transcriptional repressor and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA.

5. Daniel et al. Biochim Biophys Acta. (2006) Model depicting the E-cadherin–catenin cell adhesion complex and signaling pathways

6. Daniel et al. Biochim Biophys Acta. (2006) Schematic representation of p120ctn and its nuclear binding partner Kaiso

7. Frodo interacts with Dishevelled to transduce Wnt signals Nat Cell Biol. (2002) Two Frodo/Dapper Homologs Are Expressed in the Developing Brain and Mesoderm of Zebrafish Dev Dyn. (2004) The involvement of Frodo in TCF-dependent signaling and neural tissue development Development. (2004) A Vertebrate Homolog of the Cell Cycle Regulator Dbf4 Is an Inhibitor of Wnt Signaling Required for Heart Development Dev Cell. (2005) Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements Dev Dyn. (2006) Frodo comes into Wnt signaling

8. Brott BK and Sokol SY. Differentiation. (2005) A role for Frd1, a Dsh-associated protein, in Wnt signaling

9. Interaction between p120-Catenin and Frodo

10. Frodo Regulation of the xKaiso Target Gene, xWnt-11 Wnt11 KCS : Kaiso consensus site CTGCNA

11. Inhibition of Kaiso:DNA Association by Frodo Figure S1.

12. Frodo Partially Rescues Kaiso-Induced Gastrulation Failures Kaiso Wnt11 PCP Dsh-∆DEP Frodo p120 Kaiso : blastopore

13. Frodo Depletion Destabilizes p120ctn while Frodo Overexpression Stabilizes p120ctn

14. Dsh Regulates p120-Catenin Protein Stability

15. Wnt-Ligand Induced Signaling Inhibits Kaiso:Promoter Association Figure S3.

16. Dsh Regulates p120-Catenin Protein Stability

17. Model of the Frodo/p120-Catenin/Kaiso Signaling Module in Relation to Wnt Ligand Activation of Frizzled/LRP Coreceptor

18. Frodo Inhibits Rho A Activity Figure S4. Frodo ?