1. Post-operative complications in meningiomas involving major dural venous sinuses
Ionuț Cărăvan *1, Iulia Maria Crișan *1, Andreia Libenciuc *1, Cristian Oancea *1
Scientific Coordinator: Prof. Ioan Ștefan Florian, M.D., Ph.D. *1, *2
*1 ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
*2 Neurosurgery Department of Cluj County Emergency Hospital

2. Background Meningiomas Post-operative complications Aim
Benign tumors – arachnoid cap cells
WHO classification*1
Post-operative complications
MDVS invasion*2
Surgeon’s skills and experience
Other factors
Aim
Analyze post-operative complications in meningiomas
*1 Kleihues P, Louis DN, Scheithauer BW, et al. The WHO classification of tumors of the nervous system.
J Neuropathol Exp Neurol Mar;61(3):215–25.
*2 Marcus DM, Aaron C, et al. Management of meningiomas involving the transverse or sigmoid sinus. Neurosurg Focus Dec;35 (6):9-18.

3. Materials & Methods Single-center single-surgeon retrospective study
257 cases admitted
between January 2008 and December 2013
Statistical analysis – EpiInfo software
X2 test

4. Operative technique Localization/ MDVS involved
Dural venous sinus handling *3
*3 Mathiesen T, Pettersson-Segerlind J, Kihlström L, et al. Meningiomas Engaging Major Venous Sinuses. World Neurosurg Jan;81(1):

5. Results Age 15-85; mean=60 Sex distribution: 62% F; 38% M
Histological Grades of Meningiomas
Age 15-85; mean=60
Sex distribution: 62% F; 38% M

6. Results Post-operative complications: 23% (59 patients)
Total recurrence rate: 18% (46 patients)
Recurrence rate in meningioma invading SSS: 21,87%

7. Results MDVS Invasion: Post-operative complications:
Higher WHO grade – OR 2,51 (CI 95% [0,98; 6,35], p= 0,03)
Male patients – OR 2,79 (CI 95% [1,52; 5,11], p<0,001)
Post-operative complications:
Major dural venous sinuses invasion
OR 2,3(CI 95% [1,21;4,41], p=0,01)
Male patients - OR 1,68 (CI 95% [0,93;3,04], p=0,07)
Higher WHO Grade OR 1,13 (CI 95% [0,38;3,23],p=0,8)

8. Discussions MDVS invasion meningiomas (OR=2,3)
MDVS invasion – WHO II-III *4
Male gender meningiomas (OR=2,79)
MDVS invasion meningiomas (OR=2,3)
Complications in Higher WHO Grade meningiomas
No significant tendency
*4 Riemenschneider MJ, Perry A, Reifenberger G. Histological classification and molecular genetics of meningiomas. Lancet Neurol Dec;5(12):

9. Discussions Strong points Limits Large series of cases (257)
Uniform series of cases
6 years (22% vs 11%) *5
Limits
Retrospective study
*5 Raza SM, Gallia GL, Brem H, et al. Perioperative and long-term outcomes from the management of parasagittal
meningiomas invading the superior sagittal sinus. Neurosurgery Oct;67:885–93.

10. Conclusions Major dural venous sinuses invasion Male patients
Higher WHO Grade

11. Future development
Prospective study

12. Thank you!