1. Date of download: 9/17/2016 Copyright © The American College of Cardiology. All rights reserved. From: Platelet Biology and Response to Antiplatelet Therapy in Women: Implications for the Development and Use of Antiplatelet Pharmacotherapies for Cardiovascular Disease J Am Coll Cardiol. 2012;59(10):891-900. doi:10.1016/j.jacc.2011.09.075 Figure Legend: Incidence of Atherothrombotic Disease in Women by Age Category Data for coronary artery disease and stroke are from the Framingham original and offspring cohort, and data on peripheral arterial disease are from the ARIC (Atherosclerosis Risk In Communities) cohort (per 1,000 person-years) (6).

2. Date of download: 9/17/2016 Copyright © The American College of Cardiology. All rights reserved. From: Platelet Biology and Response to Antiplatelet Therapy in Women: Implications for the Development and Use of Antiplatelet Pharmacotherapies for Cardiovascular Disease J Am Coll Cardiol. 2012;59(10):891-900. doi:10.1016/j.jacc.2011.09.075 Figure Legend: Platelet Aggregation Before and After Aspirin Treatment Decrease in mean platelet aggregation in platelet-rich plasma in response to various concentrations of agonists after aspirin therapy in 1,282 apparently healthy children of parents with early coronary artery disease. ADP = adenosine diphosphate.

3. Date of download: 9/17/2016 Copyright © The American College of Cardiology. All rights reserved. From: Platelet Biology and Response to Antiplatelet Therapy in Women: Implications for the Development and Use of Antiplatelet Pharmacotherapies for Cardiovascular Disease J Am Coll Cardiol. 2012;59(10):891-900. doi:10.1016/j.jacc.2011.09.075 Figure Legend: Selected Outcomes in Primary and Secondary Prevention Trials of Aspirin, by Sex CI = confidence interval.

4. Date of download: 9/17/2016 Copyright © The American College of Cardiology. All rights reserved. From: Platelet Biology and Response to Antiplatelet Therapy in Women: Implications for the Development and Use of Antiplatelet Pharmacotherapies for Cardiovascular Disease J Am Coll Cardiol. 2012;59(10):891-900. doi:10.1016/j.jacc.2011.09.075 Figure Legend: Major Bleeding by Sex and GPI Dosing Incidence of in-hospital major bleeding among women and men with acute coronary syndromes who did not receive a GP IIb/IIIa inhibitor (GPI), those who received appropriate GPI dosing, and those who received excess GPI dosing in the CRUSADE registry. Probability values represent unadjusted comparisons.

5. Date of download: 9/17/2016 Copyright © The American College of Cardiology. All rights reserved. From: Platelet Biology and Response to Antiplatelet Therapy in Women: Implications for the Development and Use of Antiplatelet Pharmacotherapies for Cardiovascular Disease J Am Coll Cardiol. 2012;59(10):891-900. doi:10.1016/j.jacc.2011.09.075 Figure Legend: Platelet Responsiveness to Aspirin and Clopidogrel Laboratory measurement of platelet responsiveness to aspirin (A) and clopidogrel (B). AA = arachidonic acid; ADP = adenosine diphosphate; ASA = acetylsalicylic acid (aspirin); COX = cyclooxygenase; GP = glycoprotein; LTA = light transmittance aggregometry; PFA = platelet function analyzer; PKA = protein kinase A; PLA 2 = phospholipase A 2 ; PRP = platelet-rich plasma; TEG = thrombelastography; VASP = vasodilator- stimulated phosphoprotein; Y = monoclonal antibodies.