1. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Update on Alopecia Areata Research Jeff Donovan MD PhD FRCPC Dermatologist Assistant Professor, University of Toronto CANAAF COME TOGETHER 2016. Toronto, ON What’s New ?

2. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Five new studies to discuss Can cholesterol medications help alopecia areata? What is platelet rich plasma (PRP) and can it help? Can glaucoma medications help? Are steroid injections better than topical steroids? Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

3. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Five new studies to discuss Can cholesterol medications help alopecia areata? What is platelet rich plasma (PRP) and can it help? Can glaucoma medications help? Are steroid injections better than topical steroids? Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

4. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Can cholesterol medications help alopecia areata?

5. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD STATINS Lower cholesterol Reduce inflammation

6. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD STUDY Highlights 19 patients Treated with simvastatin and ezetimibe 24 weeks 75 % improved hair Stopping the drug lead to hair loss Treatment of alopecia areata with simvastin/ezetimibe. Journal of the American Academy of Dermatology 2015

7. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Five new studies to discuss Can cholesterol medications help alopecia areata? What is platelet rich plasma (PRP) and can it help? Can glaucoma medications help? Are steroid injections better than topical steroids? Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

8. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD What is Platelet rich plasma ?

9. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD PRP as a new option

10. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Journal of the American Academy of Dermatology Case Reports 2015

11. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Five new studies to discuss Can cholesterol medications help alopecia areata? What is platelet rich plasma (PRP) and can it help? Can glaucoma medications help? Are steroid injections better than topical steroids? Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

12. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Topical Bimatoprost

13. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD STUDY Highlights 9 year old female Used minoxidil, steroid injections topical steroid without improvement Successful Treatment of Pediatric Alopecia Areata of the Scalp with Topical Bimatoprost Solution Pediatric Dermatology 2016

14. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD 1 drop per patch twice daily Regrowth at 1 month; full at 7 months

15. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Five new studies to discuss Can cholesterol medications help alopecia areata? What is platelet rich plasma (PRP) and can it help? Can glaucoma medications help? Are steroid injections better than topical steroids? Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

16. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD STUDY Highlights 226 patients – 113 receiving steroid injections – 113 received topical steroids Better hair growth in those receiving steroid injections Intralesional triamcinolone acetonide vs topical betamethasone valerate in the management of localized alopecia areata. J Coll Physicians Surg Pak 2015

17. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Five new studies to discuss Can cholesterol medications help alopecia areata? What is platelet rich plasma (PRP) and can it help? Can glaucoma medications help? Are steroid injections better than topical steroids? Tofacitinib and Ruxolitinib: Do these new drugs help alopecia areata?

18. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD The JAK KINASES J Invest Dermatol. 2014 Dec;134(12):2988-90. Craiglow BG1, King BA1.

19. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD STUDY Highlights 35 year old male Vitiligo and alopecia areata Hair regrowth starting at 4 weeks and signficant by three months Harris JE. Rapid skin repigmentation on oral ruxolitinib in a Patient with coexistent vitiligo and alopecia areata (AA). Journal of the American Academy of Dermatology Feb 2016

20. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD STUDY Highlights Craiglow BG et al. Topical ruxolitinib for the treatment of alopecia areata universalis. JAMA Dermatology April 2016

21. What’s New in Alopecia Areata Research ? Jul 23 2016 CANAAF COME TOGETHER 2016. Toronto, ON Jeff Donovan MD Update on Alopecia Areata Research Jeff Donovan MD PhD FRCPC Dermatologist Assistant Professor, University of Toronto CANAAF COME TOGETHER 2016. Toronto, ON JULY 23, 2016 So, what’s new ?