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Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Three Families With Amyotrophic Lateral Sclerosis.

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Presentation on theme: "Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Three Families With Amyotrophic Lateral Sclerosis."— Presentation transcript:

1 Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Three Families With Amyotrophic Lateral Sclerosis and Frontotemporal Dementia With Evidence of Linkage to Chromosome 9p Arch Neurol. 2007;64(2):240-245. doi:10.1001/archneur.64.2.240 Haplotype structure of sequence tagged site markers for the Que-23 family on chromosome 9p. Black diamonds indicate persons with amyotrophic lateral sclerosis; shaded diamonds, individuals with frontotemporal dementia only; diagonal line, deceased; arrow, lower key recombinant; parentheses, inferred alleles; and question marks, unknown genotype. Not all individuals are shown to preserve confidentiality. Figure Legend:

2 Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Three Families With Amyotrophic Lateral Sclerosis and Frontotemporal Dementia With Evidence of Linkage to Chromosome 9p Arch Neurol. 2007;64(2):240-245. doi:10.1001/archneur.64.2.240 Analysis of sequence tagged site (STS) markers for the Fr-104 family on chromosome 9p. Black diamonds indicate persons with amyotrophic lateral sclerosis (ALS); arrow, upper key recombinant; diagonal line, deceased; parentheses, inferred alleles; and question mark, unknown genotype. Individual III-5 has preliminary signs of frontotemporal dementia. Figure Legend:

3 Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Three Families With Amyotrophic Lateral Sclerosis and Frontotemporal Dementia With Evidence of Linkage to Chromosome 9p Arch Neurol. 2007;64(2):240-245. doi:10.1001/archneur.64.2.240 Haplotype analysis of sequence tagged site markers for the Que-1 family on chromosome 9p. Black diamonds indicate persons with amyotrophic lateral sclerosis; parentheses, inferred alleles; and diagonal line, deceased. Individuals IV-5, IV-7, and IV-10 also have frontotemporal dementia only. Not all collected individuals in lower generations are shown. Figure Legend:

4 Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Three Families With Amyotrophic Lateral Sclerosis and Frontotemporal Dementia With Evidence of Linkage to Chromosome 9p Arch Neurol. 2007;64(2):240-245. doi:10.1001/archneur.64.2.240 Multipoint analysis combining the 3 families in this study using GeneHunter software (version 2.1; Ward Systems Group Inc, Frederick, Md). Markers were chosen spanning the ALS-FTD locus. ALS indicates amyotrophic lateral sclerosis; FTD, frontotemporal dementia. Logarithm of odds scores are displayed on the y-axis. Figure Legend:


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