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Protein Synthesis Inhibitors. TETRACYCLINEs broad-spectrum, bacteriostatic antibiotics.

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Presentation on theme: "Protein Synthesis Inhibitors. TETRACYCLINEs broad-spectrum, bacteriostatic antibiotics."— Presentation transcript:

1 Protein Synthesis Inhibitors

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3 TETRACYCLINEs broad-spectrum, bacteriostatic antibiotics

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6 Adverse effects: Gastric discomfort Effects on calcified tissues Fatal hepatotoxicity Phototoxicity Vestibular problems Pseudotumor cerebri Superinfections

7 MACROLIDES bacteriostatic, cidal at higher doses

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12  An interaction with digoxin: the antibiotic eliminates a species of intestinal flora that ordinarily inactivates digoxin, thus leading to greater reabsorption of the drug from the enterohepatic circulation

13 CHLORAMPHENICOL either bactericidal or (more commonly) bacteriostatic, depending on the organism

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15 Adverse effects: Anemias Gray baby syndrome Interactions

16 CLINDAMYCIN

17 QUINUPRISTIN/DALFOPRISTIN Bactericidal Long postantibiotic effect

18 Adverse effects: Venous irritation Arthralgia and myalgia Hyperbilirubinemia Interactions

19 LINEZOLID Bacteriostatic cidal against the streptococci and Clostridium perfringens

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21 patients are cautioned not to consume large quantities of tyramine-containing foods

22 AMINOGLYCOSIDES Bactericid

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25 Adverse effects: Ototoxicity Nephrotoxicity Neuromuscular paralysis Allergic reactions


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