1. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Summary of evidence search and selection.VTE = venous thromboembolism. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Derivation of patient population from source studies.VTE = venous thromboembolism. * References 16 to 22. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Cox-derived cumulative hazard for recurrent VTE, by d-dimer status and patient sex (regardless of previous hormone-associated VTE).HT = hormone therapy; VTE = venous thromboembolism. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Cox-derived cumulative hazard for recurrent venous thromboembolism, by d-dimer status in patient subgroups defined by timing of d-dimer testing after anticoagulation. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Cox-derived cumulative hazard for recurrent venous thromboembolism, by d-dimer status in patient subgroups defined by age. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Cox-derived cumulative hazard for recurrent venous thromboembolism, by d-dimer status as defined by 500- and 250-µg/L cut points. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7. Date of download: 9/17/2016 From: Patient-Level Meta-analysis: Effect of Measurement Timing, Threshold, and Patient Age on Ability of d- Dimer Testing to Assess Recurrence Risk After Unprovoked Venous Thromboembolism Ann Intern Med. 2010;153(8):523-531. doi:10.7326/0003-4819-153-8-201010190-00009 Cox-derived cumulative hazard for recurrent venous thromboembolism, at 3-year follow-up, by quantitative d-dimer values.Curve truncated at 2000 µg/L. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians