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Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo by Xinhua Zhang, Yuko Kimura, Chongyun Fang, Lin Zhou, Georgia Sfyroera,

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Presentation on theme: "Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo by Xinhua Zhang, Yuko Kimura, Chongyun Fang, Lin Zhou, Georgia Sfyroera,"— Presentation transcript:

1 Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo by Xinhua Zhang, Yuko Kimura, Chongyun Fang, Lin Zhou, Georgia Sfyroera, John D. Lambris, Rick A. Wetsel, Takashi Miwa, and Wen-Chao Song Blood Volume 110(1):228-236 July 1, 2007 ©2007 by American Society of Hematology

2 LPS sensitivity of wild-type (WT) and DAF−/− mice. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

3 Effect of complement on LPS-induced cytokine production in vivo. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

4 Effect of complement on LPS-induced cytokine production by splenocytes and peritoneal macrophages in vitro. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

5 Role of NF-κB activation and MAP kinase phosphorylation in the LPS sensitivity phenotype of DAF−/− mice. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

6 Complement regulates TLR2/6 and TLR9 activation. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

7 Role of IL-10 in complement-mediated IL-12 inhibition. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

8 Diagram showing proposed interaction between complement and the TLR pathways. Xinhua Zhang et al. Blood 2007;110:228-236 ©2007 by American Society of Hematology

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