1. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cardiac Involvement in Patients With Limb-Girdle Muscular Dystrophy Type 2 and Becker Muscular Dystrophy Arch Neurol. 2008;65(9):1196-1201. doi:10.1001/archneur.65.9.1196 Left ventricular ejection fraction (LVEF) in patients with limb-girdle muscular dystrophy type 2 (LGMD2) and Becker muscular dystrophy (BMD). Each symbol represents a patient. All values are shown at nominal value except for LVEF 60%, which is clustered at and above the 60% line. IVS indicates intraventricular septum; LVEDD, left ventricular end diastolic diameter. The LVEF under 50% is delineated below both horizontal dashed lines; LVEF of 50%, between both dashed horizontal lines; and LVEF over 50%, above both horizontal dashed lines. The solid symbols mark the LVEF of the individual patient; the open symbols not only mark the LVEF of the patient but also inform us that the patient was found to have a dilated LVEDD (open diamond), marginally increased IVS (open triangle), or hypertrophy (open circle). Figure Legend:

2. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cardiac Involvement in Patients With Limb-Girdle Muscular Dystrophy Type 2 and Becker Muscular Dystrophy Arch Neurol. 2008;65(9):1196-1201. doi:10.1001/archneur.65.9.1196 Left ventricular ejection fraction (LVEF) in patients with limb-girdle muscular dystrophy type 2 (LGMD2) I (A and B), LGMD2A (C and D), LGMD2B-E (E and F), Becker muscular dystrophy (BMD) (G and H), and unclassified LGMD2 (I and J) compared with their age and muscle strength. Muscle strength was calculated as the percentage of the mean strength found in healthy sex-matched controls. There was no significant correlation between LVEF and age or percentage decreased muscle strength. The LVEF values of 60% are shown as 59% to 64%. Figure Legend:

3. Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cardiac Involvement in Patients With Limb-Girdle Muscular Dystrophy Type 2 and Becker Muscular Dystrophy Arch Neurol. 2008;65(9):1196-1201. doi:10.1001/archneur.65.9.1196 Percentage of decreased muscle strength vs decreased respiratory function (A) and cardiac involvement (B) in patients with limb- girdle muscular dystrophy type 2 and Becker muscular dystrophy. *There was a significant decrease in muscle strength in patients with decreased respiratory function (P <.001). Figure Legend: