Presentation is loading. Please wait.

Presentation is loading. Please wait.

Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion.

Published byHelen Parsons Modified over 8 years ago

Similar presentations

Presentation on theme: "Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion."— Presentation transcript:

1 Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion by Nikolaos G. Frangogiannis, Merry L. Lindsey, Lloyd H. Michael, Keith A. Youker, Robert B. Bressler, Leonardo H. Mendoza, Robert N. Spengler, C. Wayne Smith, and Mark L. Entman Circulation Volume 98(7):699-710 August 18, 1998 Copyright © American Heart Association, Inc. All rights reserved.

2 Canine heart contains sizable mast cell population. a, Control canine heart stained with toluidine blue and counterstained with fast green (×400). Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

3 Cardiac resident mast cells contain preformed TNF-α. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

4 TNF-α in canine heart is localized predominantly in mast cells. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

5 IL-1β is not constitutively expressed in canine heart. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

6 Kinetics of histamine release in postischemic cardiac lymph. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

7 Mast cell degranulation in ischemic myocardium. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

8 TNF-α immunoreactivity in ischemic and reperfused myocardium. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

9 Egress of TNF-α from mast cells in ischemic and reperfused myocardium. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

10 Release of TNF-α bioactivity in canine cardiac lymph after myocardial ischemia and reperfusion. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

11 Cellular origin of IL-6 in ischemic and reperfused myocardium (1 hour occlusion and 3 hours reperfusion). Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

12 Early appearance of IL-6 mRNA in cardiac lymph–derived leukocytes. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

13 TNF-α is an important upstream cytokine responsible for IL-6 mRNA induction in canine mononuclear cells stimulated with cardiac lymph. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

14 Schematic of cytokine cascade in myocardial ischemia and reperfusion. Nikolaos G. Frangogiannis et al. Circulation. 1998;98:699- 710 Copyright © American Heart Association, Inc. All rights reserved.

Download ppt "Resident Cardiac Mast Cells Degranulate and Release Preformed TNF-α, Initiating the Cytokine Cascade in Experimental Canine Myocardial Ischemia/Reperfusion."

Similar presentations

Trends in Hospitalizations and Outcomes for Acute Cardiovascular Disease and Stroke, 1999–2011CLINICAL PERSPECTIVE by Harlan M. Krumholz, Sharon-Lise T.

Trends in Hospitalizations and Outcomes for Acute Cardiovascular Disease and Stroke, 1999–2011CLINICAL PERSPECTIVE by Harlan M. Krumholz, Sharon-Lise T.
Targeted Deletion of Fgl-2/Fibroleukin in the Donor Modulates Immunologic Response and Acute Vascular Rejection in Cardiac Xenografts by Michael Mendicino,

Targeted Deletion of Fgl-2/Fibroleukin in the Donor Modulates Immunologic Response and Acute Vascular Rejection in Cardiac Xenografts by Michael Mendicino,
Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li.

Elastin Stabilizes an Infarct and Preserves Ventricular Function by Tomohiro Mizuno, Terrence M. Yau, Richard D. Weisel, Chris G. Kiani, and Ren- Ke Li.
Brief Increase in Carbohydrate Oxidation After Reperfusion Reverses Myocardial Stunning in Conscious Pigs by Raymond K. Kudej, Lawrence T. White, Amelia.

Brief Increase in Carbohydrate Oxidation After Reperfusion Reverses Myocardial Stunning in Conscious Pigs by Raymond K. Kudej, Lawrence T. White, Amelia.
Omega-3 Fatty Acid Blood Levels by H. Robert Superko, Scott M. Superko, Khurram Nasir, Arthur Agatston, and Brenda C. Garrett Circulation Volume 128(19):2154-2161.

Omega-3 Fatty Acid Blood Levels by H. Robert Superko, Scott M. Superko, Khurram Nasir, Arthur Agatston, and Brenda C. Garrett Circulation Volume 128(19):
Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long- term Nitric Oxide Synthase Inhibition by.

Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long- term Nitric Oxide Synthase Inhibition by.
Can Adenosine 5′-Triphosphate Be Used to Select Treatment in Severe Vasovagal Syndrome? by Daniel Flammang, Timothy Church, Marc Waynberger, Annick Chassing,

Can Adenosine 5′-Triphosphate Be Used to Select Treatment in Severe Vasovagal Syndrome? by Daniel Flammang, Timothy Church, Marc Waynberger, Annick Chassing,
Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After.

Enhanced Effect of Combining Human Cardiac Stem Cells and Bone Marrow Mesenchymal Stem Cells to Reduce Infarct Size and to Restore Cardiac Function After.
Cardioprotective Effect of a Hemoglobin-Based Oxygen Carrier on Cold Ischemia/Reperfusion Injury Cardiology 2011;120:73–83 - DOI:10.1159/000333106 Fig.

Cardioprotective Effect of a Hemoglobin-Based Oxygen Carrier on Cold Ischemia/Reperfusion Injury Cardiology 2011;120:73–83 - DOI: / Fig.
Comparison of the Short-Term Survival Benefit Associated With Revascularization Compared With Medical Therapy in Patients With No Prior Coronary Artery.

Comparison of the Short-Term Survival Benefit Associated With Revascularization Compared With Medical Therapy in Patients With No Prior Coronary Artery.
Three-dimensional Mapping of the Initiation of Nonsustained Ventricular Tachycardia in the Human Heart by Mina K. Chung, Steven M. Pogwizd, Dave P. Miller,

Three-dimensional Mapping of the Initiation of Nonsustained Ventricular Tachycardia in the Human Heart by Mina K. Chung, Steven M. Pogwizd, Dave P. Miller,
by Yehuda G. Wolf, Christopher K. Zarins, Geoffrey D

by Yehuda G. Wolf, Christopher K. Zarins, Geoffrey D
Soluble Tumor Necrosis Factor Receptor Abrogates Myocardial Inflammation but Not Hypertrophy in Cytokine-Induced Cardiomyopathy by Toru Kubota, George.

Soluble Tumor Necrosis Factor Receptor Abrogates Myocardial Inflammation but Not Hypertrophy in Cytokine-Induced Cardiomyopathy by Toru Kubota, George.
ΓδT Cell–Derived Interleukin-17A via an Interleukin-1β–Dependent Mechanism Mediates Cardiac Injury and Fibrosis in HypertensionNovelty and Significance.

ΓδT Cell–Derived Interleukin-17A via an Interleukin-1β–Dependent Mechanism Mediates Cardiac Injury and Fibrosis in HypertensionNovelty and Significance.
Circ Cardiovasc Interv

Circ Cardiovasc Interv
Oxygen Therapy in Ischemic Stroke

Oxygen Therapy in Ischemic Stroke
Functional Recovery in Aged and Young Rats After Embolic Stroke

Functional Recovery in Aged and Young Rats After Embolic Stroke
Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury by Wenjie Wang, Costas J. Schulze, Wilma.

Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury by Wenjie Wang, Costas J. Schulze, Wilma.
Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia

Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia
Vascular Progenitor Cells in Diabetes Mellitus

Vascular Progenitor Cells in Diabetes Mellitus

Similar presentations

Ads by Google