1. DECIDE: "Scientific and Clinical Perspectives“: Claudio Babiloni (UNIFG) and Giovanni Frisoni (IRCCS Brescia)

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6. AD Mild cognitive impairment (MCI) APPLICATION TO CLINICAL NEUROPHYSIOLOGY Which markers for early diagnosis, prognosis, and monitoring of Alzheimer disease? Normal elderly (Nold)

8. Structure: MR hippo volumetry Biochemistry: CSF tau/Abeta Function: FDG PET Amyloid deposits: PET Dubois, Feldman et al., Lancet Neurol 2007 Revised NIA-AA diagnostic criteria Biomarkers

9. Genetic risk of AD: ApoE4 9 Jack et al., 2010, Lancet Neurology

10. Staging AD with dynamic biomarkers: CSF, PET and MRI 10 Jack et al., 2010, Lancet Neurology

12. DEVELOP STANDARDIZED OPERATIONAL PROCEDURES FOR DIAGNOSTIC MARKERS ModalityCollectionMeasurement Hippocampal volume 3D T1 MR ADNI protocol Alzheimer’s Association / EADC-ADNI harmonized protocol (under development) Temporo-parietal hypometabolism FDG PET ADNI protocol Head-to-head comparison of scores (under development) CSF Ab42 and tau Lumbar puncture Alzheimer’s Association protocol (under development) Cortical amyloid deposition Amyloid PET None

13. Basic methodology: 10-20 electrode montage and LORETA for source analysis of resting eyes-closed EEG 10-20 electrode system Resting eyes closed (2 min), eyes open (2 min) LORETA LORETA solutions averaged with cortical lobes (frontal, central, parietal, temporal, occipital, limbic) Psychometric testing and neurological evaluation CHEAP, NON-INVASIVE, AND DIFFUSE CANDIDATE MARKERS FOR FIRST SCREENING: RESTING STATE EEG

14. Babiloni C, Binetti G, Cassetta E, Cerboneschi D, Dal Forno G, Del Percio C, Ferreri F, Ferri R, Lanuzza B, Miniussi C, Moretti DV, Nobili F, Pascual-Marqui RD, Rodriguez G, Romani GL, Salinari S, Tecchio F, Vitali P, Zanetti O, Zappasodi F, Rossini PM. Mapping distributed sources of cortical rhythms in mild Alzheimer's disease. A multicentric EEG study. Neuroimage. 2004; 22(1): 57-67. Posterior sources of resting alpha rhythms were lower in power in mild AD than VaD subjects, despite similar degree of global cognition. Resting EEG data: 38 Nold 48 mild AD 20 VaD