1. Modeled Exposure Assessment via Inhalation and Dermal Pathways to Airborne Semivolatile Organic Compounds (SVOCs) in Residences Shanshan Shi and Bin Zhao. Environ. Sci. Technol. 2014, 48, 5691−5699 hEX-Tox Lab. Paper reading HyeYoung Choi 2015-02-25

2. Author information 2015-02-25hEX-Tox paper reading2

3. Introduction 2015-02-25hEX-Tox paper reading3 SVOCs? omnipresent organic compounds DEHP (generated indoor sources), PAHs (indoor & outdoor) Use : plasticizers, fire retardants, and the main ingredients of pesticides Source : anthropogenic activities (ex. combustion activities)

4. Introduction 2015-02-25hEX-Tox paper reading4 Goal An integrated framework was established by combining a kinetic partition model for SVOCs phase-specific concentrations estimation and an exposure assessment model.

5. Introduction 2015-02-25hEX-Tox paper reading5 How to know about exposure to SVOCs? Personal monitoring, biomarkers Modeling

6. Introduction 2015-02-25hEX-Tox paper reading6 Ref) Jian Yan et al. (Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 557, 1. 2004) 16 PAHs from the US EPA priority pollutant list Phe Pyr BaP BghiP

7. Materials and Methods 2015-02-25hEX-Tox paper reading7 1.Indoor SVOCs Concentrations Modeling

8. Materials and Methods 2015-02-25hEX-Tox paper reading8 1.Indoor SVOCs Concentrations Modeling

9. Materials and Methods 2015-02-25hEX-Tox paper reading9 2.Exposure Assessment Modeling “reference people”

10. Materials and Methods 2015-02-25hEX-Tox paper reading10 2.Exposure Assessment Modeling modeled indoor SVOCs phases specific concentrations exposure factors exposure of “reference people” to airborne SVOCs via different pathways

11. Materials and Methods 2015-02-25hEX-Tox paper reading11 2.Exposure Assessment Modeling

12. Materials and Methods 2015-02-25hEX-Tox paper reading12 3.Input Parameters and Scenarios PAHs were considered to combine only with PM 2.5. the atmospheric daily particle-phase PAHs concentrations were assumed to be proportional to the corresponding atmospheric daily PM 2.5 concentrations.

13. Results and Discussion 2015-02-25hEX-Tox paper reading13 1.Indoor SVOCs Phase-specific Concentrations 2 yr (730 day) Eq 4-7 Black line : Gas-phase Blue line : Particle-phase

14. Results and Discussion 2015-02-25hEX-Tox paper reading14 1.Indoor SVOCs Phase-specific Concentrations Ref16 : Hangzhou; nonsmoking families Ref27 : Xuanwei and Fuyuan Ref29 : Sapporo(Jap) DEHP airbone Range : 251-1530

15. Results and Discussion 2015-02-25hEX-Tox paper reading15 2.Exposure Assessment for SVOCs Indoor gas-phase Phe Conc. : 81.8 mg/m 3 Indoor ED : 20.35 hr/day 62.29 kg IR : 12.7 m 3 /day Indoor inhalation exposure gas- phase Conc. : 14.1 ng/kg/day Outdoor inhalation exposure gas- phase Conc. : 2.26 ng/kg/day Eq 8

16. Results and Discussion 2015-02-25hEX-Tox paper reading16 2.Exposure Assessment for SVOCs

17. Results and Discussion 2015-02-25hEX-Tox paper reading17 2.Exposure Assessment for SVOCs

18. Results and Discussion 2015-02-25hEX-Tox paper reading18 3.The Barrier Effect of Clothing Barrier ?Or not ?

19. Results and Discussion 2015-02-25hEX-Tox paper reading19 4.Implications for Further Work

20. 2015-02-25hEX-Tox paper reading20 Thank you!

21. Appendix_A 2015-02-25hEX-Tox paper reading21 Study chemicals among 16 PAHs from the US EPA priority pollutant list 화합물색상 융점 ( ℃ ) 비점 ( ℃ ) 증기압 (Pa, 25 ℃ ) 밀도 옥탄올 - 물분배 계수 (Log K ow ) 수용해도 ( ㎍ /ℓ, 25 ℃ ) Phenanthrene 무색 100.53401.6×10 -2 0.9804.61.29×10 3 Pyrene 무색 150.43936.0×10 -4 1.2715.18135 Benzo(a)pyrene 황색 178.14967.3×10 -7 1.3516.503.8 Benzo(ghi)perylene 엷은황녹색 278.35451.4×10 -8 1.3297.100.26 PhePyrBaPBghiP

22. Appendix_B 2015-02-25hEX-Tox paper reading22 1.Indoor SVOCs Phase-specific Concentrations PhePyrBaPBghiP the mass fraction of particle-phase within the total airborne concentration 0.030.310.950.96 the average mass fraction of particle-phase0.050.130.970.99