1. Date of download: 9/18/2016 From: Primary Treatment of Acquired Aplastic Anemia: Outcomes with Bone Marrow Transplantation and Immunosuppressive Therapy Ann Intern Med. 1997;126(2):107-115. doi:10.7326/0003-4819-126-2-199701150-00003 Cumulative incidence of long-term complications. Top.Bottom.Cumulative incidence of rejection or evolution of a secondary malignant condition in patients having bone marrow transplantation. Cumulative incidence of evolution of a myelodysplastic syndrome or acute leukemia, paroxysmal nocturnal hemoglobinuria (PNH) or recurrent aplasia after immunosuppressive therapy. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2. Date of download: 9/18/2016 From: Primary Treatment of Acquired Aplastic Anemia: Outcomes with Bone Marrow Transplantation and Immunosuppressive Therapy Ann Intern Med. 1997;126(2):107-115. doi:10.7326/0003-4819-126-2-199701150-00003 Actuarial survival after therapy for acquired aplastic anemia. Top.Bottom.PSurvival of 168 patients who had bone marrow transplantation. Survival of 227 patients who received immunosuppressive therapy. Tick marks denote censoring times of surviving patients. The difference in actuarial survival between patients who had transplantation and those who received immunosuppressive therapy was statistically significant ( < 0.001; log- rank test). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3. Date of download: 9/18/2016 From: Primary Treatment of Acquired Aplastic Anemia: Outcomes with Bone Marrow Transplantation and Immunosuppressive Therapy Ann Intern Med. 1997;126(2):107-115. doi:10.7326/0003-4819-126-2-199701150-00003 Effect of patient age on actuarial survival by treatment group.PPPPTick marks denote censoring times of surviving patients. A. Patient age, younger than 6 years; 12 patients had transplantation and 25 patients received immunosuppressive therapy ( = 0.006). B. Patient age, 6 to 19 years; 63 patients had transplantation and 62 patients received immunosuppressive therapy ( = 0.001). C. Patient age, 20 to 39 years; 82 patients had transplantation and 73 patients received immunosuppressive therapy ( = 0.04). D. Patient age, 40 years or older; 11 patients had transplantation and 67 patients received immunosuppressive therapy ( > 0.2). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4. Date of download: 9/18/2016 From: Primary Treatment of Acquired Aplastic Anemia: Outcomes with Bone Marrow Transplantation and Immunosuppressive Therapy Ann Intern Med. 1997;126(2):107-115. doi:10.7326/0003-4819-126-2-199701150-00003 Effect of transfusion status on actuarial survival by treatment group. Top.PBottom.PSurvival of 53 transplant recipients who did not receive transfusion and 115 transplant recipients who received transfusion ( = 0.04; log- rank test). Survival of 41 patients who received immunosuppressive therapy and did not receive transfusion and 174 patients who received immunosuppressive therapy and transfusion ( = 0.11; log-rank test). Tick marks denote censoring times of surviving patients. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5. Date of download: 9/18/2016 From: Primary Treatment of Acquired Aplastic Anemia: Outcomes with Bone Marrow Transplantation and Immunosuppressive Therapy Ann Intern Med. 1997;126(2):107-115. doi:10.7326/0003-4819-126-2-199701150-00003 Effect of the absolute neutrophil count (ANC) before therapy on actuarial survival by treatment group.PP9999Tick marks denote censoring times of surviving patients. > 0.2 for the bone marrow transplantation group and = 0.002 for the immunosuppressive therapy group. In the bone marrow transplantation group, 98 patients had an absolute neutrophil count greater than 2.0 × 10 /L and 70 had a count less than 2.0 × 10 /L. In the immunosuppressive therapy group, 133 patients had an absolute neutrophil count greater than 2.0 × 10 /L and 94 had a count less than 2.0 × 10 /L. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians