1. AstraZeneca R&D Boston Waltham Energy Reduction Initiative 2016 Green Labs Symposium

2. SiteAstraZeneca Boston Biohub Size65 acres LocationWaltham, Massachusetts Buildings6 R&D Lab Buildings 1 Office Building 1 Central Utility Plant Multi Level Parking Structure No. of Employees700 Facilities404,000 sq ft total Multi-tenant; Drug Discovery and Early Clinical Development. Therapeutic areas: Infection, Oncology, Neuroscience, Business Development and New Opportunities

3. 2007 – 2009 Before Metering Retro Commissioning Base Buildings –ABC (170,000 sq. ft.) –MN (80,000 sq. ft.) Night Setback Strategy Changes in Temperature Control –AHU –Labs and Offices Formed Site Energy Team –Fume Hood Face Velocity Reductions –Sash Management How Much Did We Save?

4. 2010 to 2015 Five Year Plan Data Acquisition Dashboard and Metering Form Internal & External Energy Teams –Local Utilities MOU Collect, Evaluate, Prioritize Ideas – Local Utilities Feasibility Studies Technical Assessments Execute the Plan Validate Savings and Reinvest

5. 2011 Projects M&N Air Flow Reductions –Air flow stations –Optimizing BAS Sequence of Operations Site Wide Holiday Unoccupied Schedule –Scheduling by Building/Floor Plate Scheduled Static Pressure Reset –Supply and Exhaust Headers Air Balance C0 Lab –~13,000 CFM Reduction Parking Garage Lighting

6. 2012 Projects Modified Exhaust Cones – A & B BLDGS Select Laboratories Air Flow Reductions Autoclave Steam Switching –Summer time shutdown chemical-free steam generator Free Cooling Optimization Chilled Water Plant –Install VFDs on Primary Pumps 1, 2, & 4 –Low flow weirs on cooling towers 1 & 2 –Software changes – HEX and chiller operation Leaving Chilled Water Temperature Reset Schedule Chillers Lighting Retrofit – ABCMN, Site, and CUP –Bulbs & Ballasts and Daylight Harvesting

7. 2013 Projects Install 19 VFD on Misc Fans and Pumps Data Center CRAC Optimization –VFD –Chilled Water Flow Control Valves Schedule Pumps OFF when BLDG D is Unoccupied Night Setback of CAFE Daytime Unoccupied Controls in Meeting Rooms and Auditorium

8. 2014 Projects Chiller Plant Optimization –Control System Upgrade –Chiller Flow Control Upgrade –Graphical User Control Interface Deep Night Set Back in Lab and Offices –Lower Header Static Pressures Supply and Exhaust –Reduced Air Exchange Rates to 3ACH Where Possible Building Automation System Audit

9. Site Total Electric kW October 2011 vs. April 2015

10. Total Lab Supply Air CFM October 2011 vs. July 2015

11. Chiller Plant Optimization Variable Leaving Water Temperature and Variable Condenser Flow k