1. Early Childhood Epilepsy Severity Scale (E-CHESS) Humphrey A et al. Epilepsy Research (2008) 79: 139—145. 1. Frequency of seizures 2. Time period over which seizures occurred 3. Number of seizure types 4. Number of anticonvulsants used 5. Response to treatment

2. Summary of Clinical Characteristics: +PGES, n = 26 Male 16(62%); Female 10(38%) Mean Age Epilepsy Onset, yr (SD; Range): 5.9 (5.4; 0 – 16) Mean Duration of Epilepsy, yr (SD; Range): 7.2 (3.6; 2.1 – 16.4) Mean # Seizure Types (Range): 3 (1 – 6) Mean # Lifetime AEDs (SD, Range): 5 (2.7; 2 – 11) Developmental Disability: 16(62%) GDD (50%) ADHD (25%) ASD (13%) LD (13%)

3. Longer PGES Duration Significantly Correlates with Presence of GTCS Mann-Whitney U Test 35 s p < 0.005 9.6s

4. Longer PGES Duration Significantly Correlates with Lower E-Chess Score Simple Regression Analysis

5. Longer PGES Duration Significantly Correlates with Less Lifetime Use of AEDs Simple Regression Analysis

6. Longer PGES Duration Significantly Correlates with Absence of GDD 37.7s p < 0.005 17.7s Mann-Whitney U Test