1. function Enrichment Score Enrichment p- value % genes in group that are present # genes in list, in group positive regulation of fever generation14.73713.98E-07503 positive regulation of nitric oxide biosynthetic process14.49325.08E-0716.66674 peroxidase activity12.08985.62E-0623.07693 haptoglobin-hemoglobin complex10.67762.31E-0566.66672 sequestering of triglyceride10.67762.31E-0566.66672 positive regulation of calcidiol 1-monooxygenase activity10.67762.31E-0566.66672 negative regulation of cell proliferation9.528747.27E-052.272736 humoral immune response9.178580.0001032279.090913 immune response9.143140.0001069512.120146 oxygen transport9.073320.00011468533.33332 regulation of I-kappaB kinase/NF-kappaB cascade9.073320.00011468533.33332 inflammatory response8.702910.0001661022.61785 ovulation8.452630.000213339252 positive regulation of chemokine biosynthetic process8.452630.000213339252 chemokine activity8.380970.0002291876.976743 positive regulation of membrane protein ectodomain proteolysis8.203050.00027381822.22222 oxygen transporter activity7.981640.00034168202 hemoglobin complex7.981640.00034168202 negative regulation of lipid catabolic process7.78270.00041688618.18182 positive regulation of cell death7.602110.00049939816.66672 positive regulation vascular endothelial growth factor production7.602110.00049939816.66672 embryonic digestive tract development7.602110.00049939816.66672 positive regulation of NF-kappaB import into nucleus7.284370.00068618314.28572 hydrogen peroxide catabolic process7.01120.0009017312.52 response to vitamin D7.01120.0009017312.52 response to glucocorticoid stimulus6.664590.001275283.89613 neutrophil chemotaxis6.662220.0012783110.52632 positive regulation of interferon-gamma production6.460230.001564439.523812 positive regulation of mitosis6.460230.001564439.523812 cellular component movement6.379160.001696543.529413 positive regulation of interleukin-6 production6.192130.002045478.333332 cell cycle arrest6.183310.002063583.29673 response to organic nitrogen6.110470.002219582 calcium-mediated signaling6.032160.00240037.692312 embryo implantation5.956930.002587857.407412 memory5.956930.002587857.407412 heme binding5.942670.002625013.03033 chemotaxis5.914070.0027011833 external side of plasma membrane5.857770.00285762.941183 oxygen binding5.814820.002983036.896552 positive regulation of JNK cascade5.747550.003190586.666672 response to organic cyclic compound5.722090.003272872.803743 protein heterooligomerization5.619780.003625456.252 positive regulation of smooth muscle cell proliferation5.442970.004326615.714292 response to hydrogen peroxide5.387540.004573215.555562 extracellular space5.087530.006173240.9771996 extracellular matrix organization5.039620.006476244.651162 positive regulation of ERK1 and ERK2 cascade4.866590.007699554.255322 regulation of blood pressure4.785810.008347374.081632 positive regulation of sequence-specific DNA binding transcription factor activity4.785810.008347374.081632 extracellular region4.594390.01010840.7067148 Table S6. GO categories down-regulated in late acute phase vs convalscent phase(p <0.05) (HG-focus platform)

2. Figure S6 Continued anti-apoptosis4.536750.01070811.829273 positive regulation of protein phosphorylation4.52820.01080013.571432 regulation of insulin secretion4.460840.01155273.448282 positive regulation of NF-kappaB transcription factor activity4.333210.01312543.225812 activation of MAPK activity4.302660.01353253.17462 response to estradiol stimulus3.947050.01931162.631582 apoptosis3.600950.02729770.9685234 leukocyte migration3.550240.02871772.127662 positive regulation of I-kappaB kinase/NF-kappaB cascade3.492210.03043352.061862 sugar binding3.278320.03769171.834862 signal transduction3.250090.03877080.6543086 response to lipopolysaccharide3.24520.03896081.80182 response to drug3.220260.03994461.107013 angiogenesis3.103960.04487121.666672 cytokine activity3.0890.04554761.652892