1. Molly – a newly popular club drug

2. “Molly” may refer to 2 different drugs  1. MMDA, the main constituent of Ecstasy  2. TFMPP, a non-controlled synthetic drug with properties similar to Ecstasy, often mixed with other drugs

3. TFMPP  1-(3-Trifluoromethylphenyl) piperazine  AKA Legal E, Legal X or A2  An off white powder sold in gelatin capsules, often mixed with other drugs, esp. BZP (benzylpiperazine)  Popular among HS and College students attending Rave Parties  Escalating abuse since 2004 when no longer controlled under CSA

4. TFMPP Pharmacology  Serotonin releasing agent (like MMDA)  Mild and mellow high  Mild halluinogen  Anti-aggressive  Locomotor inhibition  Hyperthermia  Repiratory depression

5. However TFMPP seldom sold alone!  Usually mixed with BZP (benzylpiperazine) for its norepinephrine and dopinergic effects.  TFMPP + BZP combo has norepi +dopinergic + serotonin like effects, similar to MMDA  Marketed as a legal Ecstasy  However BZP is controlled under CSA

6. TFMPP + BZP Side Effects  Tachycardia, hypertension  Insomnia, anxiety  Nausea and vomiting  Headaches, myalgia, hangover  Palpitations and agitation  Seizures (including status)  Rhabdomyolysis, renal failure

7. Psychosis  Uncommon  More related to BZP than TFMPP  Amphetamine psychosis manifested by hallucinations, delusions and paranoia  Symptoms usually disappear after a few weeks.

8. Treatment  Supportive  Benzodiazepines  Treat seizures unresponsive to benzodiazepines with phenobarbital

9. References  http://www.deadiversion.usdoj.gov/drugs_concern/tfmp p.pdf http://www.deadiversion.usdoj.gov/drugs_concern/tfmp p.pdf  http://informahealthcare.com/doi/abs/10.3109/15563650. 2011.572076 http://informahealthcare.com/doi/abs/10.3109/15563650. 2011.572076  http://journal.nzma.org.nz/journal/118-1227/1784/ http://journal.nzma.org.nz/journal/118-1227/1784/  http://www.toxinz.co.nz/Demo/6/TjA2QkFYWDEwLzAy OA%3D%3D#secrefID0EU6DI http://www.toxinz.co.nz/Demo/6/TjA2QkFYWDEwLzAy OA%3D%3D#secrefID0EU6DI  http://www.partyade.com/info.php http://www.partyade.com/info.php  http://journal.nzma.org.nz/journal/122-1303/3794/ http://journal.nzma.org.nz/journal/122-1303/3794/