1. Hematocrit Volume of red blood cells in a sample (45%)

2. Erythrocytes Hemopoiesis - Formation of blood cells (occurs in the bone marrow) Lack a nucleus and organelles Biconcave shape – Form a rouleaux to pass through capillaries Contains hemoglobin

3. Hemoglobin Red pigment that transports oxygen and carbon dioxide Consist of 4 proteins, 4 iron ions – Can bind 4 oxygen molecules

4. Erythrocyte Production The hormone erythropoietin (EPO) controls RBC production and is produced in the kidneys More EPO is made if there are low levels of oxygen in the blood – If more EPO is made, what will be the effect on the body?

5. Stimulus Receptor Control Center Effector Homeostasis Change in variable Structure that detects change in variable Initiates change based on input from receptor Structure that causes change to stimulus Internal balance returned Afferent pathway Efferent pathway

6. Blood Doping An illegal procedure used by athletes to try to boost their body’s ability to deliver oxygen to the muscles by increasing RBC – Blood becomes more viscous, so the heart has to work harder to pump blood  cardiovascular damage

7. Hemostasis Process where the blood clots and stops blood flow through an injured blood vessel wall 1.Vascular Spasm – blood vessel constricts to prevent leakage 2.Platelet Plug Formation – platelets stick to damaged fibers in the blood vessel wall to form a plug (positive feedback) 3.Coagulation Phase – blood clot is formed

8. Create a flowchart to represent the stages of hemostasis

9. Circulatory Diseases Sickle Cell Anemia Leukemia Hematoma Hemophilia Lymphoma