1. 80 60 40 20 0 Procathepsin B concentration, ng/mL Age 18-40 (n=14) Age 41-55 (n=10) Age 56-80 (n=8) The data are shown as mean±SEM ** - p <0,001 vs control serum # - p <0,05 Benign Ovarian tumor vs Ovarian Cancer 600 800 400 200 0 1000 Control (n=32) Benign Ovarian Tumor (n=9) (n=6) Ovarian Cancer (II-IV stage) (n=14) (n=11) Procathepsin B concentration, ng/mL Serum Abdominal exudate Ascites fluid ** a b # # Figure 1

2. 60 80 40 20 0 100 120 Serum Abdominal exudate Ascites fluid Control (n=10) Benign Ovarian Tumor (n=9) (n=6) Ovarian Cancer (II-IV stage) (n=14) (n=11) Cystatin B concentration, ng/mL ** * The data are shown as mean±SEM * - p < 0,05; ** - p <0,001 vs control serum # - p <0,05 Benign Ovarian tumor vs Ovarian Cancer (serum) # Figure 2

3. Cystatin C concentration, ng/mL 600 800 400 200 0 1000 1200 1400 Control n=10 Benign Ovarian tumor (n=9) (n=6) Ovarian Cancer (II-IV stage) (n=13) Serum Abdominal exudate Ascites fluid * The data are shown as mean±SEM * - p < 0,05; vs control serum # - p <0,05 Benign Ovarian tumor vs Ovarian Cancer (Ascites) # Figure 3