1. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Nonhormonal Therapies for Menopausal Hot Flashes: Systematic Review and Meta-analysis JAMA. 2006;295(17):2057-2071. doi:10.1001/jama.295.17.2057 RCTs indicates randomized controlled trials; SSRIs, selective serotonin reuptake inhibitors; SNRIs, serotonin norepinephrine reuptake inhibitors. Articles identified from database searches were subjected to inclusion and exclusion criteria for the systematic review and meta-analysis.*Some trials had more than 1 reason for exclusion. Figure Legend:

2. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Nonhormonal Therapies for Menopausal Hot Flashes: Systematic Review and Meta-analysis JAMA. 2006;295(17):2057-2071. doi:10.1001/jama.295.17.2057 CI indicates confidence interval; SERM, selective estrogen receptor modulator. Six trials of 4 SSRIs or SNRIs provided data for meta-analysis.*Controlled release forms of paroxetine and extended release forms of venlafaxine.†Data for 150-mg/d dose were not included because this dose was substantially higher than the other dosages.‡Data for 20-mg/d dose at 3 months of follow-up were included to improve consistency with the other trials.§Includes references 29-32. ∥ Includes references 22 and 23. Figure Legend:

3. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Nonhormonal Therapies for Menopausal Hot Flashes: Systematic Review and Meta-analysis JAMA. 2006;295(17):2057-2071. doi:10.1001/jama.295.17.2057 CI indicates confidence interval; SERM, selective estrogen receptor modulator. Four trials of clonidine provided data for meta- analysis: 3 trials used 0.1-mg/d dose and 1 trial used a range of doses (0.05-0.15 mg/d).*Includes references 45 and 46.†Includes references 38 and 41. Figure Legend:

4. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Nonhormonal Therapies for Menopausal Hot Flashes: Systematic Review and Meta-analysis JAMA. 2006;295(17):2057-2071. doi:10.1001/jama.295.17.2057 CI indicates confidence interval. Six trials of 2 types of red clover isoflavones provided data for meta-analysis. Figure Legend:

5. Date of download: 9/18/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Nonhormonal Therapies for Menopausal Hot Flashes: Systematic Review and Meta-analysis JAMA. 2006;295(17):2057-2071. doi:10.1001/jama.295.17.2057 CI indicates confidence interval. Six trials of soy isoflavone extracts provided data for meta-analysis.*Participants have breast cancer, with 78% taking tamoxifen. Figure Legend: