1. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT- HF) JAMA. 2000;283(10):1295-1302. doi:10.1001/jama.283.10.1295 CR/XL indicates controlled release/extended release. Figure Legend:

2. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT- HF) JAMA. 2000;283(10):1295-1302. doi:10.1001/jama.283.10.1295 Cumulative (all-cause) withdrawal of study drug has also been illustrated,including 310 patients in the placebo group and 279 in the controlled-release/extended-releasemetoprolol (metoprolol CR/XL) group. Figure Legend:

3. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT- HF) JAMA. 2000;283(10):1295-1302. doi:10.1001/jama.283.10.1295 CR/XL indicates controlled release/extended release. Figure Legend:

4. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT- HF) JAMA. 2000;283(10):1295-1302. doi:10.1001/jama.283.10.1295 Filled squares indicate subgroups with a total of 180 events or more;open squares, subgroups with a total of less than 180 events (low power);CR/XL, controlled release/extended release; NYHA, New York Heart Association;EF, ejection fraction; AMI, acute myocardial infarction; HR, heart rate; SBP,systolic blood pressure; and DBP, diastolic blood pressure. Figure Legend:

5. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT- HF) JAMA. 2000;283(10):1295-1302. doi:10.1001/jama.283.10.1295 CR/XL indicates controlled release/extended release. Relative differencesbetween the groups are given in percentages. Figure Legend:

6. Date of download: 9/19/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Effects of Controlled-Release Metoprolol on Total Mortality, Hospitalizations, and Well-being in Patients With Heart Failure: The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT- HF) JAMA. 2000;283(10):1295-1302. doi:10.1001/jama.283.10.1295 CR/XL indicates controlled release/extended release. Zero indicatesno change; − 7, maximum deterioration; and 7, maximum improvement. Asignificant (P =.009) improvement was observed inthe metoprolol CR/XL group vs the placebo group. Figure Legend: