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Published byRaymond Atkinson Modified over 8 years ago
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Lipid classification 1.simple lipids ---fats 脂肪 ---waxes 蠟類 (page 229) 2.complex lipids ---phospholipids 磷脂類 (A) glycerophospholipids 甘油磷脂類 (B) sphingophospholipids 神經鞘磷脂類 ---glycolipids(glycosphingolipids) 醣脂質 ---other complex lipids e.g sulfolipids, aminolipid, lipoprotein etc. 3.precursor and derived lipids 3 Fatty acids 脂肪酸 + glycerol 甘油 Page 219
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三酸甘油酯 ROH + R’COOH R’COOR + H2O Page 219 Fats 脂肪
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Structural formulas of some C 18 fatty acids. Page 219 Fatty Acid 脂肪酸 COO - under physiological condition
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Page 220 Common in nature common Nomenclature 命名法 1.Systemic nomenclatures 2.Common name 俗名 saturated vs. unsaturated monounsaturated & polyunsaturated 硬脂酸 油酸 棕櫚酸
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Composition of hydrocarbon tails in phospholipids FluidViscous Unsaturated hydrocarbon tails with kinks Saturated hydro- Carbon tails Page 220
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乙酸 丙酸 Page 220
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Page 221
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Page 222 cis fatty acids vs. trans fatty acids
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三酸甘油酯 ROH + R’COOH R’COOR + H2O Page 222 Triacylglycerols 三酸甘油酯
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Page 222 (common name)
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Page 229 Waxes
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Lipid classification 1.simple lipids ---fats 脂肪 ---waxes 臘類 (page 229) 2.complex lipids ---phospholipids 磷脂類 (A) glycerophospholipids 甘油磷脂類 (B) sphingophospholipids 神經鞘磷脂類 ---glycolipids(glycosphingolipids) 醣脂質 ---other complex lipids e.g sulfolipids, aminolipid, lipoprotein etc. 3.precursor and derived lipids 3 Fatty acids 脂肪酸 + glycerol 甘油 Page 224
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2.Complex lipids ---phospholipids 磷脂類 (A) glycerophospholipids 甘油磷脂類 (B) sphingophospholipids 神經鞘磷脂類 ---glycolipids(glycosphingolipids) 醣脂質 ---other complex lipids e.g sulfolipids, aminolipid, lipoprotein etc.
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Phospholipid
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磷脂酸 (lecithin) (Diphosphatidylglycerol) Page 225
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Structures of Several Glycerophospholipids Page 225
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*Amphipathic molecules (hydrophophilic & hydrophobic region) 兩者 Page 225
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Page 226 (PAF) Ether glycerophospholipids (A) ethanolamine
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(B) Page 227 Phospholipase resistance
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Page 227
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神經醯胺 神經胺基醇 Page 228
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Choline (or ethanolamine)
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Glycolipid
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Page 228 Sugar(s) + ceramide =
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ceramide Page 228 *Tay-Sachs disease
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Abnormal ganglioside deposits in the lysosome Page 228
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Terpenes ---combinations of two or more molecules of 2-methyl-1,3-butadiene (isoprene): Isoprene is the chemical 2-methyl-1,3- butadiene: Page 229
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Derivatives of isoprene Page 260
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Steroids Page 233
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Page 234
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Cholestrol
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1.The dual effects of cholesterol on membrane fluidity ---decrease membrane fluidity at high temperature ---increase membrane fluidity at low temperature 2.Sterols (cholesterol in animal) decrease the permeability of a lipid bilayer to ions and small polar molecules. Functions of cholesterol on membrane:
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Fig. 8-18a, p. 234
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Fig. 8-19, p. 235
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Fig. 8-20, p. 237
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