1. Chang Kyun Lee, MD, Suck-Ho Lee, MD, Il-Kwun Chung, MD, Tae Hoon Lee, MD, Sang-Heum Park, MD, Eun-Ok Kim, RN, Sae Hwan Lee, MD, Hong-Soo Kim, MD, Sun-Joo Kim, MD GASTROINTESTINAL ENDOSCOPY Volume 73, No. 2 : 2011 소화기내과 R3. 고원진 Balanced propofol sedation for therapeutic GI endoscopic procedures Journal conference 2011.03.07

2. Propofol sedation for GI endoscopy has become popular worldwide. However, propofol monosedation is not risk free with interventional endoscopy.  Propofol sedation for GI endoscopy remains a highly controversial issue Balanced propofol sedation (BPS) Combines small incremental doses of propofol with single induction doses of benzodiazepines and opioids Background

3. Purpose In patients undergoing therapeutic GI endoscopic procedures Conventional group : Midazolam + Meperidine BPS group : Midazolam + Meperidine + Propofol VSVS

4. PATIENTS AND METHODS

5. Sedation protocols - The conventional group Midazolam (0.05mg/kg body weight)  Meperidine 25 mg  Repeated doses of 1 to 2 mg midazolam - The BPS group Both midazolam and meperidine were given in the same manner  Propofol (0.5 mg/kg body weight)  Repeated doses of 10 to 20 mg propofol PATIENTS AND METHODS

6. Outcome measurements and definitions - The primary outcomes 1) Cardiopulmonary complications 2) The frequency of interruption of the procedures - Secondary outcomes 1) procedure-related times 2) Postprocedure assessment PATIENTS AND METHODS

7. Results 1)Study population and baseline characteristics 2)Mean total dose of drugs used and procedure- related times Safety profiles 3)Safety profiles 4)Postprocedure assessment

8. Study population and baseline characteristics

9. Mean total dose of drugs used and procedure-related times Safety profiles

10. Safety profiles

11. Postprocedure assessment

12. BPS provided higher health care provider satisfaction, better patient cooperation, and similar adverse event profiles in patients undergoing therapeutic endoscopic procedures. Conclusion