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Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction:

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Presentation on theme: "Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction:"— Presentation transcript:

1 Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study by Vladimir Džavík, Gad Cotter, Harmony R. Reynolds, John H. Alexander, Krishnan Ramanathan, Amanda L. Stebbins, David Hathaway, Michael E. Farkouh, E. Magnus Ohman, David A. Baran, Roland Prondzinsky, Julio A. Panza, Warren J. Cantor, Zvi Vered, Christopher E. Buller, Neal S. Kleiman, John G. Webb, David R. Holmes, Joseph E. Parrillo, Stanley L. Hazen, Steven S. Gross, Robert A. Harrington, and Judith S. Hochman EHJ Volume (): April 25, 2007 © The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

2 (A) l-NMMA concentration–time profiles for the four treatment groups and placebo group. Vladimir Džavík et al. Eur Heart J 2007;eurheartj.ehm075 © The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

3 Steady-state l-NMMA concentration and infusion rate. Vladimir Džavík et al. Eur Heart J 2007;eurheartj.ehm075 © The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

4 Change in MAP 2 h after initiation of study drug bolus and infusion. Vladimir Džavík et al. Eur Heart J 2007;eurheartj.ehm075 © The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

5 Proportion of patients in each study group with vasopressor down-titration prior to 2 h. Vladimir Džavík et al. Eur Heart J 2007;eurheartj.ehm075 © The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

6 Change in MAP 15 min after initiation of study drug bolus and infusion. Vladimir Džavík et al. Eur Heart J 2007;eurheartj.ehm075 © The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

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