1. Dengue Fever Diana Lopez BIOL 62

3. “I felt severe body aches- even my eye balls hurt. The fever was high and I just felt like sleeping to avoid the pain.” -Diana B. Lopez

4. Severity of Dengue Fever Symptoms vary depending on whether it is your first or second viral infection First Viral Strain Encounterd 10 Days Flu-like Symptoms Second Viral Strain Encountered Dengue Hemorrhagic Fever Dengue Shock Syndrome

5. Dengue is caused by a flavivirus with a single stranded RNA genome

6. Aedes Mosquito Flaviviruses, including those which cause Dengue, West Nile infection, and Yellow Fever, are all transmitted by mosquitos

7. Protect Yourself from Mosquito Bites! While Outside Heavily Populated Areas RepellantsNets Long sleeves and pants While Inside Doors and screens Air Conditioning Prevention is the key

8. WHO played a big role in creating DengueNet

9. Without a vaccine or antiviral medication, treatment is restricted to managing symptoms HydrateRest Acetamin -ophen Avoid Aspirin!

10. An ideal test will diagnose the Dengue virus and strain Direct Detection Virus isolation Genome detection Antigen detection Indirect Detection 5 days after symptoms begin IgM antibodies Primary infection IgG antibodies Secondary infection Detected after months

11. There are a number of methods of diagnosing Dengue virus

12. Dengue primarily affects tropical countries in the developing world 100 million new cases per year Denguematters Newsletter Rapid Spread

13. It can lead to a “Downhill Spiral of Debt” Infection/Re- infection Adults Miss Work Loss of Income Treatment is expensive and distant Forced to sell property/ Loans

14. Purpose of Research Population Biology Transmission Patterns Aedes Mosquito Vector Biology is one key area of research

15. A live, attenuated Dengue vaccine is under development, but has yet to reach the targeted full protection A safe vaccine is possible! Serotype-specific efficacy of the CYD tetravalent Dengue vaccine against Dengue disease

18. Sources http://www.webmd.com/a-to-z-guides/dengue-fever- reference http://www.nature.com/scitable/topicpage/current- dengue-fever-research-22404441 http://www.denguematters.info/content/issue-1-human- costs-dengue http://www.niaid.nih.gov/topics/DengueFever/Research/B asicResearch/pages/howdenguematures.aspx http://jgv.sgmjournals.org/content/89/12/3047.full http://www.sciencedirect.com/science/article/pii/S014067 3612614287

19. Photographs http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.n ature.com%2Fscitable%2Ftopicpage%2Fdengue-viruses- 22400925&ei=O4lWVPqLKIOhgwSU6YLYBg&bvm=bv.78677474,d.eXY&psig=AFQjCNE4Pm_UQSnxMrklbpvZAvdJoogZuA&ust=14150 43676566363 http://www.1zoom.net/Nature/wallpaper/310853/z886.1/ http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.b ajainsider.com%2Fbaja- life%2Fhealth%2Fdenguefever.htm&ei=9o5WVPOuGoiegwTlsIHgDw&bvm=bv.78677474,d.eXY&psig=AFQjCNFlz- Ezzf2ps76GCMjoBvKm_Me1Ww&ust=1415045233513344 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.cl ipartguide.com%2F_pages%2F0511-0811-2403- 4401.html&ei=gJRWVI3oCsSrNvj5gvAH&bvm=bv.78677474,d.eXY&psig=AFQjCNHebLGhVYDXPNeoEoavd5pYYiD4zA&ust=14150466 15526344 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.pi nterest.com%2Fbluehorsefarm%2Fclip- art%2F&ei=pZRWVJXhLoeegwSC0YCgDA&bvm=bv.78677474,d.eXY&psig=AFQjCNHebLGhVYDXPNeoEoavd5pYYiD4zA&ust=14150 46615526344 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fcureden gue.blogspot.com%2F2012%2F10%2Fcuring-dengue- fever.html&ei=zpxWVKTrOsmmNuqggMAB&bvm=bv.78677474,d.eXY&psig=AFQjCNFt6gezJRAYoM- eh53pS99ZahPZiA&ust=1415048778543851 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.n ature.com%2Fscitable%2Ftopicpage%2Fdengue-viruses- 22400925&ei=O4lWVPqLKIOhgwSU6YLYBg&bvm=bv.78677474,d.eXY&psig=AFQjCNE4Pm_UQSnxMrklbpvZAvdJoogZuA&ust=14150 43676566363 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.p anama-guide.com%2Farticle.php%2F2006030616243927&ei=eUNYVKCyFIKZgwTJ- YOwCQ&bvm=bv.78677474,d.eXY&psig=AFQjCNGTg8FuEpztQapibr6PC2ZLiz_8hg&ust=1415156964440350 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F%2Fwww.tr opika.net%2Fsvc%2Freview%2F061001- Dengue_Recent_epidemiological_trends&ei=9sZYVK6AGISngwSfi4HwDQ&bvm=bv.78677474,d.eXY&psig=AFQjCNGzJNeHaN6xkPJouu GNLl6rY_9m1w&ust=1415190593392893 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&ved=0CAcQjRw&url=http%3A%2F%2Fwww.leaplocal.org%2Fho w-to-go-local%2Fhealth%2Fmalaria-and-insect-borne- diseases%2F&ei=dsxYVPSzGIKVNu_rg5AP&bvm=bv.78677474,d.eXY&psig=AFQjCNGQ3fxFK7tRRMd6LPwwFP2OtR7L3Q&ust=14151 92043841669 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F %2Fwww.kiwicollection.com%2Fhotel-detail%2Ftortuga- bay&ei=9tNYVJWkD8uqNvTEg4gI&bvm=bv.78677474,d.eXY&psig=AFQjCNGc6jSwYSo2x3NPyeaSw4vSbGnXfA&ust=141 5193631065151 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F %2Fwww.climate-change-guide.com%2Fdengue- fever.html&ei=RqFZVPrCMveOsQTDkYDIBg&bvm=bv.78677474,d.cWc&psig=AFQjCNEE1iNEDIqX0fNC- 6mcdYuKNw5YKg&ust=1415246517545115 http://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAcQjRw&url=http%3A%2F %2Fen.wikipedia.org%2Fwiki%2FCasualties_of_the_2010_Haiti_earthquake&ei=b6NZVJ6MLcWagwSts4GgDw&bvm=bv.7867 7474,d.cWc&psig=AFQjCNFTF_LEp9mT2oIrarZAyEYZjGiKbQ&ust=1415246966502218