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Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR ‐ bound and RBR ‐ free complexes by Zoltán Magyar, Beatrix Horváth, Safina.

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Presentation on theme: "Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR ‐ bound and RBR ‐ free complexes by Zoltán Magyar, Beatrix Horváth, Safina."— Presentation transcript:

1 Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR ‐ bound and RBR ‐ free complexes by Zoltán Magyar, Beatrix Horváth, Safina Khan, Binish Mohammed, Rossana Henriques, Lieven De Veylder, László Bakó, Ben Scheres, and László Bögre EMBO J. Volume 31(6):1480-1493 March 21, 2012 ©2012 by European Molecular Biology Organization

2 Both RBR1 and E2FA are present in proliferating cells in Arabidopsis roots and leaves. Zoltán Magyar et al. EMBO J. 2012;31:1480-1493 ©2012 by European Molecular Biology Organization

3 E2FA silencing leads to compromised cell proliferation and endocycle. Zoltán Magyar et al. EMBO J. 2012;31:1480-1493 ©2012 by European Molecular Biology Organization

4 RBR1 makes complex with E2FA in proliferating cells while it associates with E2FB in cells leaving cell proliferation. Zoltán Magyar et al. EMBO J. 2012;31:1480-1493 ©2012 by European Molecular Biology Organization

5 The pE2FA::gE2FA–GFP lines have increased expression of E2FA within its own expression domain that leads to more proliferation and endocycle compared with WT. (A) Two independent pE2FA::gE2FA–GFP lines (line 2/10 and line 81/11) were tested for the expressi... Zoltán Magyar et al. EMBO J. 2012;31:1480-1493 ©2012 by European Molecular Biology Organization

6 E2FA interaction with RBR1 is required for the repression of premature cell elongation and endocycle. Zoltán Magyar et al. EMBO J. 2012;31:1480-1493 ©2012 by European Molecular Biology Organization

7 Model explaining the functions of E2FA and E2FB in proliferating and in endocycling cells. Zoltán Magyar et al. EMBO J. 2012;31:1480-1493 ©2012 by European Molecular Biology Organization


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