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Gli3 Regulation of Myogenesis Is Necessary for Ischemia- Induced AngiogenesisNovelty and Significance by Marie-Ange Renault, Soizic Vandierdonck, Candice.

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Presentation on theme: "Gli3 Regulation of Myogenesis Is Necessary for Ischemia- Induced AngiogenesisNovelty and Significance by Marie-Ange Renault, Soizic Vandierdonck, Candice."— Presentation transcript:

1 Gli3 Regulation of Myogenesis Is Necessary for Ischemia- Induced AngiogenesisNovelty and Significance by Marie-Ange Renault, Soizic Vandierdonck, Candice Chapouly, Yang Yu, Gangjian Qin, Alexandre Metras, Thierry Couffinhal, Douglas W. Losordo, Qinyu Yao, Annabel Reynaud, Béatrice Jaspard-Vinassa, Isabelle Belloc, Claude Desgranges, and Alain- Pierre Gadeau Circulation Research Volume 113(10):1148-1158 October 25, 2013 Copyright © American Heart Association, Inc. All rights reserved.

2 Gli3 is overexpressed in regenerating skeletal muscle. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

3 Endothelial Cell Gli3 is not required for ischemia-induced angiogenesis. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

4 Skeletal muscle regeneration is impaired in HSA-CreERT2; Gli3Flox/Flox mice. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

5 Myogenesis is delayed in HSA-CreERT2; Gli3Flox/Flox mice. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

6 Gli3 regulates myoblast differentiation. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

7 Muscle Gli3 regulates ischemia-induced angiogenesis. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

8 E2F1 regulates Gli3 expression in myoblasts. Marie-Ange Renault et al. Circ Res. 2013;113:1148-1158 Copyright © American Heart Association, Inc. All rights reserved.

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