1. Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase ‐ 3 inhibition by Francois Renault ‐ Mihara, Hiroyuki Katoh, Takeshi Ikegami, Akio Iwanami, Masahiko Mukaino, Akimasa Yasuda, Satoshi Nori, Yo Mabuchi, Hirobumi Tada, Shinsuke Shibata, Ken Saito, Masayuki Matsushita, Kozo Kaibuchi, Seiji Okada, Yoshiaki Toyama, Masaya Nakamura, and Hideyuki Okano EMBO Mol Med. Volume 3(11):682-696 November 2, 2011 ©2011 by European Molecular Biology Organization

2. Ro3303544 is more potent than a previously utilized GSK ‐ 3 inhibitor. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

3. Sustained, but not acute, inhibition of GSK ‐ 3 by Ro3303544 stimulates the migration of astrocytes and reduces their spreading in vitro. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

4. In vivo administration of Ro3303544 for the first 5 days after SCI in mice is effective. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

5. Administration of Ro3303544 after SCI accelerates the compaction of infiltrated inflammatory cells by stimulating reactive astrocyte migration. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

6. Treatment with Ro3303544 reduces the size of the lesion scar at 14 DPI. A. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

7. Administration of Ro3303544 reduces demyelination and promotes functional recovery after contusive SCI. A. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

8. Gene microarray analysis examining the effects of sustained GSK ‐ 3 inhibition by Ro3303544 on primary astrocyte cultures. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

9. Gene expression differences of selected gene clusters. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

10. Increased migration of astrocytes in vitro upon prolonged Ro3303544 treatment relies on reduced cell adhesion with the ECM due to decreased surface expression of β1 ‐ integrin. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization

11. The Ro3303544 ‐ mediated reduction of β1 ‐ integrin expression in the spinal cord is concomitant with the spontaneous upregulation of laminin at 10 DPI. A. Francois Renault ‐ Mihara et al. EMBO Mol Med. 2011;3:682- 696 ©2011 by European Molecular Biology Organization