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MiRNA-130a regulates C/EBP-ε expression during granulopoiesis by Maria T. Larsen, Mattias Häger, Andreas Glenthøj, Fazila Asmar, Stine N. Clemmensen, Helena.

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Presentation on theme: "MiRNA-130a regulates C/EBP-ε expression during granulopoiesis by Maria T. Larsen, Mattias Häger, Andreas Glenthøj, Fazila Asmar, Stine N. Clemmensen, Helena."— Presentation transcript:

1 miRNA-130a regulates C/EBP-ε expression during granulopoiesis by Maria T. Larsen, Mattias Häger, Andreas Glenthøj, Fazila Asmar, Stine N. Clemmensen, Helena Mora-Jensen, Niels Borregaard, and Jack B. Cowland Blood Volume 123(7):1079-1089 February 13, 2014 ©2014 by American Society of Hematology

2 Expression of miR-130a and C/EBP-ε during human granulopoiesis. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology

3 The miR-130a and C/EBP-ε expression in ATRA-induced MPRO cells. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology

4 Target verification of miR-130a in C/EBP-ε 3 ʹ -UTR. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology

5 The miR-130a affects cell growth and expression of mRNAs encoding specific granule protein. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology

6 Expressing a C/EBP-ε mRNA unaffected by miR-130a partially restores the phenotype of the pEGP-miR-130a clone. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology

7 MPRO cells overexpressing miR-130a resists ATRA-induced differentiation. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology

8 Regulation of C/EBP-ε by miR-130a in human granulocytic precursors. Maria T. Larsen et al. Blood 2014;123:1079-1089 ©2014 by American Society of Hematology


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