1. Date of download: 9/20/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers Arch Gen Psychiatry. 2004;61(1):73-84. doi:10.1001/archpsyc.61.1.73 Locations of methamphetamine (MA)and control group differences in relative regional cerebral glucose metabolicrate (rCMRglc). Statistical parametric maps were generated using SPM99 (WellcomeDepartment of Cognitive Neurology, London, England) for the contrast of relativerCMRglc in the control group (n = 18) greater than in the MA abuser group(n = 17) and also for the contrast of relative rCMRglc in the MA abuser groupgreater than in the control group. Colors superimposed on the gray-scale structuralmagnetic resonance template indicate areas where the height threshold forthe contrast (whole brain) was t≥1.69 (P=.049). Locations where clusters exhibited P<.05for spatial extent (corrected for search volume of the relevant region ofinterest but not the number of regions) are noted (Table 4). Coordinates are in MNI space (Montreal Neurological Institute,Toronto, Ontario). igACC indicates infragenual anterior cingulate cortex;pgACC, perigenual anterior cingulate cortex. Figure Legend:

2. Date of download: 9/20/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers Arch Gen Psychiatry. 2004;61(1):73-84. doi:10.1001/archpsyc.61.1.73 Locations of positive covariationbetween relative regional cerebral glucose metabolic rate (rCMRglc) and BeckDepression Inventory (BDI) score in the methamphetamine (MA) abuser group(n = 18) (top row) and locations of positive covariation between relativerCMRglc and BDI score in the control group (n = 17)(bottom row). Colors superimposedon the gray-scale structural magnetic resonance template indicate areas wherethe height threshold for the contrast (whole brain) was t≥1.69 (P=.049). Locations where clustersexhibited P<.05 for spatial extent (correctedfor search volume of the relevant region of interest but not the number ofregions) are noted (Table 5).There were no significant clusters with BDI score as a negative covariateof relative rCMRglc. Coordinates are in MNI space (Montreal Neurological Institute,Toronto, Ontario). igACC indicates infragenual anterior cingulate cortex;pgACC, perigenual anterior cingulate cortex. Figure Legend:

3. Date of download: 9/20/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Mood Disturbances and Regional Cerebral Metabolic Abnormalities inRecently Abstinent Methamphetamine Abusers Arch Gen Psychiatry. 2004;61(1):73-84. doi:10.1001/archpsyc.61.1.73 Locations of covariation betweenrelative regional cerebral glucose metabolic rate (rCMRglc) and trait anxiety(State-Trait Anxiety Inventory score) in the methamphetamine abuser group(n = 13). Colors superimposed on the gray-scale structural magnetic resonancetemplate indicate areas where the height threshold for the contrast (wholebrain) was t≥1.69 (P=.049). Locations where clusters exhibited P<.05for spatial extent (corrected for search volume of the relevant region ofinterest but not the number of regions tested) are noted (Table 6). Coordinates are in MNI space (Montreal Neurological Institute,Toronto, Ontario). igACC indicates infragenual anterior cingulate cortex;pgACC, perigenual anterior cingulate cortex. Figure Legend: