1. Increasing Annual Cost of Diabetes <15-9 50-70 10-1430-49 Total Annual Direct Medical and Indirect Societal Costs of Diabetes in Billions of Dollars* 1-4 20-29 *Constant 2015 Dollars 15-19 Total US $408 B Institute for Alternative Futures 2014 Diabetes Model based on Boyle, Projection of the year 2050 burden of diabetes in the US adult population, http://www.pophealthmetrics.com/content/8/1/29 ; CDC, National Diabetes Statistics Report, 2014; Dall, The Economic Burden of Elevated Blood Glucose Levels in 2012: Diagnosed and Undiagnosed Diabetes, Gestational Diabetes Mellitus, and Prediabetes, Diabetes Care 2014;37:3172-3179; CDC diabetes trends, US Census Bureau http://www.pophealthmetrics.com/content/8/1/29 2015

2. Increasing Annual Cost of Diabetes <15-9 50-70 10-1430-49 Total Annual Direct Medical and Indirect Societal Costs of Diabetes in Billions of Dollars* 1-4 20-29 *Constant 2015 Dollars 15-19 Total US $491 B Institute for Alternative Futures 2014 Diabetes Model based on Boyle, Projection of the year 2050 burden of diabetes in the US adult population, http://www.pophealthmetrics.com/content/8/1/29 ; CDC, National Diabetes Statistics Report, 2014; Dall, The Economic Burden of Elevated Blood Glucose Levels in 2012: Diagnosed and Undiagnosed Diabetes, Gestational Diabetes Mellitus, and Prediabetes, Diabetes Care 2014;37:3172-3179; CDC diabetes trends, US Census Bureau http://www.pophealthmetrics.com/content/8/1/29 2020

3. Increasing Annual Cost of Diabetes <15-9 50-70 10-1430-49 Total Annual Direct Medical and Indirect Societal Costs of Diabetes in Billions of Dollars* 1-4 20-29 *Constant 2015 Dollars 15-19 Total US $564 B Institute for Alternative Futures 2014 Diabetes Model based on Boyle, Projection of the year 2050 burden of diabetes in the US adult population, http://www.pophealthmetrics.com/content/8/1/29 ; CDC, National Diabetes Statistics Report, 2014; Dall, The Economic Burden of Elevated Blood Glucose Levels in 2012: Diagnosed and Undiagnosed Diabetes, Gestational Diabetes Mellitus, and Prediabetes, Diabetes Care 2014;37:3172-3179; CDC diabetes trends, US Census Bureau http://www.pophealthmetrics.com/content/8/1/29 2025

4. Increasing Annual Cost of Diabetes <15-9 50-70 10-1430-49 Total Annual Direct Medical and Indirect Societal Costs of Diabetes in Billions of Dollars* 1-4 20-29 *Constant 2015 Dollars 15-19 Total US $622 B Institute for Alternative Futures 2014 Diabetes Model based on Boyle, Projection of the year 2050 burden of diabetes in the US adult population, http://www.pophealthmetrics.com/content/8/1/29 ; CDC, National Diabetes Statistics Report, 2014; Dall, The Economic Burden of Elevated Blood Glucose Levels in 2012: Diagnosed and Undiagnosed Diabetes, Gestational Diabetes Mellitus, and Prediabetes, Diabetes Care 2014;37:3172-3179; CDC diabetes trends, US Census Bureau http://www.pophealthmetrics.com/content/8/1/29 2030