1. Chapter 9 Cell Cycle and Cancer

2. Figure 17-1 Molecular Biology of the Cell (© Garland Science 2008) Cell Cycle

3. Figure 17-2 Molecular Biology of the Cell (© Garland Science 2008) Major events of cell cycle

4. Regulation of Animal Cell Cycles by Growth Factors Regulation of Animal Cell Cycles by Growth Factors

5. Identification of Mitosis-promoting Factors (MPFs) Identification of Mitosis-promoting Factors (MPFs)

6. Accumulation and Degradation of Cyclins Accumulation and Degradation of Cyclins

7. Figure 17-15 Molecular Biology of the Cell (© Garland Science 2008) Two key components of cell-cycle control system http://www.albertcheng.info/MotifMarker.htm

8. Figure 17-17 Molecular Biology of the Cell (© Garland Science 2008) Structural basis of Cdk activation

9. Complexes of Cyclins and Cyclin-Dependent Kinases Complexes of Cyclins and Cyclin-Dependent Kinases Cdk1

10. Induction of D-Type Cyclins Induction of D-Type Cyclins

11. Targets of CDKs Targets of CDKs Cdk1

12. Figure 17-19 Molecular Biology of the Cell (© Garland Science 2008) Inhibition of a cyclin-Cdk complex by a CKI

13. Cdk Inhibitors Cdk Inhibitors

14. Figure 17-18 Molecular Biology of the Cell (© Garland Science 2008) Regulation of Cdk activity by inhibitory phosphorylation Regulation of Cdk activity by inhibitory phosphorylation

15. Mechanisms of Cdk Regulation Mechanisms of Cdk Regulation

16. Figure 17-25 Molecular Biology of the Cell (© Garland Science 2008) The activation of M-Cdk The activation of M-Cdk Mitosis G 2 phaseM phase

17. Cell Cycle Checkpoints Cell Cycle Checkpoints

18. Action of p53 Action of p53

19. Induction of p21 by p53 activation Induction of p21 by p53 activation PCNA: proliferating cell nuclear antigen

20. pRb Mutation and Tumor Development pRb Mutation and Tumor Development Loss of heterozygosity

21. Phosphorylation of pRB by Cyclin/CDK complexesPhosphorylation of pRB by Cyclin/CDK complexes

22. Cell Cycle Regulation of Rb and E2F Cell Cycle Regulation of Rb and E2F Cdk4/cyclin D Cdk2/cyclin A or E p16

23. Cell Cycle Regulation of p53 and pRb Mouse double minute 2 homolog (MDM2, E3 ubiquitin-protein ligase) DNA

24. Stages of Mitosis in an Animal Cell Stages of Mitosis in an Animal Cell Mitosis

25. Fluorescence Micrographs of Chromatin, Keratin, and Microtubules During Mitosis Fluorescence Micrographs of Chromatin, Keratin, and Microtubules During Mitosis

26. Three Classes of Microtubules Three Classes of Microtubules

27. Cell Cycle Checkpoints Cell Cycle Checkpoints

28. Cell Cycle Arrest at the G1, S, and G2 Checkpoints Cell Cycle Arrest at the G1, S, and G2 Checkpoints

29. Signal Transduction by DNA Damage Signal Transduction by DNA Damage Damage sensor molecules Signal transducers Effector molecules

30. Comparison of Meiosis and Mitosis Comparison of Meiosis and Mitosis Meiosis

31. DNA Recombination at Synaptonemal ComplexDNA Recombination at Synaptonemal Complex

32. Chromosome Segregation in Meiosis I Chromosome Segregation in Meiosis I

33. Meiosis of Vertebrate Oocytes Meiosis of Vertebrate Oocytes

34. Activity of MPF During Oocyte Meiosis Activity of MPF During Oocyte Meiosis

35. Identification of Cytostatic Factor Identification of Cytostatic Factor

36. Mos Protein Kinase, a Cytostatic Factor Mos Protein Kinase, a Cytostatic Factor

37. Fertilization and Completion of Meiosis Fertilization and Completion of Meiosis

38. The Fertilization Process The Fertilization Process

39. Signal Transduction by DNA Damage Signal Transduction by DNA Damage Cell-Cycle Checkpoints

40. Signaling Cascades mediated by ATM and ATRSignaling Cascades mediated by ATM and ATR

41. Cell Cycle Checkpoints Cell Cycle Checkpoints

42. Cell Cycle Arrest at the G1, S, and G2 Checkpoints Cell Cycle Arrest at the G1, S, and G2 Checkpoints

43. Figure 17-18 Molecular Biology of the Cell (© Garland Science 2008) Regulation of Cdk activity by inhibitory phosphorylation

44. Cdk2 Cdc45 Cell Cycle Arrest at G 1 - or S-phase Cell Cycle Arrest at G 1 - or S-phase

45. Cdk2 Cdc45 Cell Cycle Arrest at G 1 - or S-phase Cell Cycle Arrest at G 1 - or S-phase

46. Cdk2 Cdc45 Cell Cycle Arrest at G 1 - or S-phase Cell Cycle Arrest at G 1 - or S-phase

47. ATM/ATR-mediated G 2 Arrest ATM/ATR-mediated G 2 Arrest

48. Spindle Checkpoint (M-phase Arrest) Spindle Checkpoint (M-phase Arrest)

49. Figure 17-44 Molecular Biology of the Cell (© Garland Science 2008) The initiation of sister-chromatid separation by the APC/C The initiation of sister-chromatid separation by the APC/C Mitosis (cleaving Scc1)

50. Cell Cycle and Cancer

51. Stages of Tumor Development Stages of Tumor Development

52. Density-Dependent Inhibition Density-Dependent Inhibition

53. Contact Inhibition Contact Inhibition

54. Invasiveness and Metastasis of Cancer Cells Invasiveness and Metastasis of Cancer Cells

55. Oncogenes of Human Tumors Oncogenes of Human Tumors

56. The Raf Oncogene Protein The Raf Oncogene Protein

57. Oncogenes and Signal Transduction Oncogenes and Signal Transduction

58. Tumor Suppressor Genes Tumor Suppressor Genes

59. Multiple Mutations in Colon Carcinomas Multiple Mutations in Colon Carcinomas

60. Cdk4/cyclin D Cdk2/cyclin A or E p16 pRb in Cancer pRb in Cancer

61. Mouse double minute 2 homolog (MDM2, E3 ubiquitin-protein ligase)

62. ATM in Cancer ATM in Cancer

63. p53 in Cancer p53 in Cancer MDM2 E6

64. p53 in Cancer p53 in Cancer Mouse double minute 2 homolog (MDM2, E3 ubiquitin-protein ligase)

65. CHEK1 and CHEK2 in Cancer CHEK1 and CHEK2 in Cancer