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Published byGarry Shields Modified over 8 years ago
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[1] Ophir, Jonathan, et al. "Elastography: a quantitative method for imaging the elasticity of biological tissues." Ultrasonic imaging (1991) [2] Muthupillai, R., et al. "Magnetic resonance elastography by direct visualization of propagating acoustic strain waves." Science (1995)
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Air-pulse OCE ( cornea ) [3] mm-OCE (Rat liver and chicken muscle) [6] Mechanical actuator for tissue phantom [4] [3] Wang, Shang, and Kirill V. Larin. "Shear wave imaging optical coherence tomography (SWI-OCT) for ocular tissue biomechanics." Optics letters (2014) [4] Nguyen, Thu-Mai, et al. "Shear wave pulse compression for dynamic elastogrcoherence tomography." Journal of biomedical optics (2014) [5] Song, Shaozhen, et al. "Quantitative shear-wave optical coherence elastography with a programmable phased array ultrasound as the wave source." Optics letters (2015) [6] Ahmad, Adeel, et al. "Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waphy using phase-sensitive optical aves." Biomedical optics express (2014) Ultrasound as wave source (porcine retina) [5]
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Megahertz Optical Coherence Elastography ~1.5 MHz A-scan rate New scanning mechanism compared to conventional OCE
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Sample Air-pulse Excitation OCT Scan Path [3] Wang, Shang, and Kirill V. Larin. "Shear wave imaging optical coherence tomography (SWI-OCT) for ocular tissue biomechanics." Optics letters (2014)
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Sample Air-pulse Excitation OCT Scan Path
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Megahertz OCE system ~1.5 MHz A-scan rate 4X Buffered FDML OptoRes Gmbh 1316 nm central wavelength 100 nm bandwidth 16 µm axial resolution Up to 160 mW of power 7.3 kHz resonant scanner Lorentz force excitation system Waveform generator Power amplifier Two magnets Probe
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Future work Improve the SNR of displacement signal; Electrical current Magnetic field Tissue conductivity Analyze tissue viscoelasticity by elastic wave dispersion Frequency analysis
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