1. Chapter 14: Chromosome 14 mRNA transcription translation Amino acid sequence Name of Protein DNA Sequence Name of Gene Chromosome What does this protein make up or do? Condition/Disease PSEN1 14 87,257 presenilin 1 467 aa Carries out the major function of the complex, which is to cut apart (cleave) other proteins into smaller pieces called peptides Alzheimer Disease

2. Description of Alzheimer’s ■ Symptoms and characteristics ■ Alzheimer Disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually even the ability to carry out the simplest tasks of daily living. ■ If you have Alzheimer, you may be the first person to notice you have unusual difficulty remembering things and thoughts. ■ The average life expectancy for people with Alzheimer’s Disease is 10 to 8 years after diagnosis. In some cases I can be short as 3 year or as long as 20 years. http://stevetallamy.com/dementia/ http://omrf.org/wp- content/uploads/2010/03/alzheimers -frontpage1.jpg

3. Description of Alzheimer's ■ Who is affected? Anyone, but the following have a higher risk: ■ Primarily people over age 65 ■ Nearly half of all individuals who reach the age 85 will develop Alzheimer's. ■ Outlook or quality of life ■ Research shows that by 2050 11 million to 16 million people will have Alzheimer's. ■ Alzheimer’s disease usually starts out slow, but eventually results into severe brain damage. ■ The actual cause of death isn't the disease itself, the actual cause of death is usually is a physical illness such as pneumonia. ■ Treatment can slow the process of the disease in some people, but relieving symptoms can improve function significantly. ■ Researcher: KB

4. References ■ Emedicinehealth. Genes and Disease: Alzheimer’s Disease [online]. 2015. [cited 2015 March 18]. Available at URL: http://www.emedicinehealth.com/alzheimer_disease/page8_em.htm#medical_treatment http://www.emedicinehealth.com/alzheimer_disease/page8_em.htm#medical_treatment ■ Huffpost Healthy Living. AOL livestyle [online]. 2015. [cited 2015 March 18]. Available at URL: http://www.huffingtonpost.com/2012/10/12/alzheimers- disease-progress-research_n_1961924.html http://www.huffingtonpost.com/2012/10/12/alzheimers- disease-progress-research_n_1961924.html ■ Genetics Home Reference. U.S. National Library Medical Chromosome 14. [online]. 2015. [cited March 18]. Available at URL: http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp. http://www.nei.nih.gov/health/glaucoma/glaucoma_facts.asp