1. Characteristics of Life  Organisms respond to their environment Organisms respond to their EXTERNAL environment Organisms respond to their EXTERNAL environment Organisms respond to their INTERNAL environment Organisms respond to their INTERNAL environment

2. The Human Body  Human require many systems for digestion, respiration, reproduction, circulation, excretion, movement, coordination, & immunity  The components of the human body, from organ systems to cell organelles, interact to maintain homeostasis.

3. What is Homeostasis?  The maintenance of a constant environment in the body… BALANCE  Achieved by many different internal controls mechanisms that detect deviations and make corrective actions.  If there is a disruption in any human body system there may be a corresponding disruption in homeostasis

4. Homeostasis Conditions within the body must remain within a narrow range – like your body temperature Homeostasis Conditions within the body must remain within a narrow range – like your body temperature Homeostasis involves keeping the internal environment within set ranges Homeostasis involves keeping the internal environment within set ranges

5. Control systems help maintain homeostasis. Control systems help maintain homeostasis. 1.sensors gather data 2. control center receives data, sends messages 3. communication system delivers messages to target organs, tissues 4. targets respond to change pore sweat glands hair follicle muscle goose bump

6. Why Homeostasis?  Body cells work best if they have the correct environment Temperature Temperature Water levels Water levels Glucose concentration Glucose concentration  Your body has mechanisms to keep the cells in a constant environment OR Dynamic Equilibrium (balanced, but fluctuates)

7. Homeostasis In order to maintain homeostasis the body uses feedback loops. There are 2 types of feedback loops: Negative Feedback Loop Negative Feedback Loop Positive Feedback Loop Positive Feedback Loop

8. It is a process by which a receptor, an integrator and an effector detects processes and responds to a change in a body constant so that a reverse affect takes place. Negative feedback is when the response takes the system BACK TO “NORMAL” This allows the body to stay constant (maintain homeostasis) Negative Feedback

10. Homeostasis Lab Lab Group of 4

11. Examples of Homeostasis & Negative Feedback Mechanisms 1. Temperature Regulation 2. Regulation of Blood Sugar Levels 3. pH Balance 4. ……and remember the stomates and guard cells in plants

12. Humans maintain a relatively constant body temperature of about 37° C. when we "heat up" we sweat if possible the evaporation of this perspiration returns the body to its original temperature Negative Feed Back: Human Body Temperature Regulation

13. Receptor Proteins Receptor Proteins are the 1st part of a feedback loop, and are found in every cell, in every organ & tissue. Send nerve impulses to brain as a result of environmental stimulants. For example: receptor proteins on skin cells detect changes in temperature and send that information to the brain. If nerve or hormone signal are blocked, cellular communication is disrupted and homeostasis is affected.

14. Outside Cell Cell Membrane Inside Cell Receptor Protein

15. Integrator (The Brain) 2nd part of negative feedback loop Sends messages to glands, muscles and/or organs The brain receives information from the receptor proteins and sends a message to either the sweat glands or the muscle cells.

16. Effector (part of the body) 3rd part of negative feedback loop. Receptor proteins receive info from brain causing a change in internal conditions. Sweat glands enable the body to cool off when they produce sweat and muscle cells enable the body to warm up when they contract (shivering). Hair follicle 1 - Sweat gland 2 - Sebaceous gland 3- Muscle 3

17. RECEPTOR PROTEINS ( ON CELLS) EFFECTORS (PARTS OF BODY) RESPONSE = SHIVERING INTEGRATOR (BRAIN) EFFECTORS (PARTS OF BODY) RESPONSE=SWEAT Heat Lost Heat Gained

18. Negative Feedback Loop: Home heating system  Thermostat is set at a desired temp.  Furnace turns on and heats the house to desired temp  When desired temp is reached the furnace turns off.  The house cools & temp drops below the desired temp. the furnace turns on & the house warms back up to desired temp.

19. Negative Feedback Controlling Glucose Levels  Your cells also need an exact level of glucose in the blood.  Excess glucose gets turned into glycogen in the liver  This is regulated by 2 hormones (chemicals) from the pancreas called: InsulinGlucagon

20. Increase in Blood Glucose Level  After eating blood glucose level increases  Brain sends message to pancreas to release insulin into blood  Insulin allows body cells to absorb glucose  Insulin also stimulates the liver to convert some glucose into glycogen ( a form of stored energy)  The result…..blood glucose level decreases & homeostasis occurs.

21. If there is too much glucose in the blood, Insulin converts some of it to glycogen Glycogen Insulin Glucose in the blood

22. Diabetes  Some people do not produce enough insulin.  When they eat food, the glucose levels in their blood cannot be reduced.  This condition is known as Type 1 DIABETES.  Diabetics have to inject insulin into their blood, continually monitor their blood glucose levels, and be careful of their diet.  Diabetes can lead to other health conditions including glaucoma & poor circulation.

23. Time Glucose Concentration Meal eaten Insulin is produced and glucose levels fall to normal again. Glucose levels rise after a meal. Normal

24. Time Glucose Concentration Meal eaten Insulin is not produced so glucose levels stay high Glucose levels rise after a meal. Diabetic

25. Negative Feedback: Decrease in Blood Glucose Level After not eating for a while blood glucose level decreases. Brain sends a message to the pancreas to release glucagon ( a type of protein) into the blood Glucagon stimulates the liver to convert glycogen (stored energy) into glucose Glucose levels in the blood increases & the body returns to homeostasis

26. If there is not enough glucose in the blood, Glucagon converts some glycogen into glucose. Glycogen Glucagon Glucose in the blood

27. Body Systems Involved in Blood Glucose Regulation Endocrine system: produces insulin and glucagon (hormones/proteins) Circulatory System: transports hormones (insulin & glucagon), glucose & glycogen to cells in the body. Nervous System: stimulates a response by sending and receiving messages to & from cells….as a result glucose levels increase or decrease.

28. Acids/ Bases/pH Scale pH Scale: Indicates the concentration of H + ions in solution pH levels must be maintained Especially for digestion to work properly

29. Acids  pH of less than 7 (Example: HCl) Bases pH of greater than 7 (Example: Bleach, Ammonia pH of greater than 7 (Example: Bleach, Ammonia

30. Buffers Weak acids or bases that can react with strong acids or bases to prevent sharp changes in pH.  These are important for maintaining a constant internal environment…..homeostasis (between 6.5 and 7.5 for most cells)  Think of treatments used for stomach aches  For digestive enzymes to work properly, pH balance must be maintained To test for acid & bases: Litmus paper base = blue acid = red

31. Remember…Homeostasis in Plants Negative Feedback Mechanism Maintenance of Water plants need to regulate water loss and carbon dioxide intake for photosynthesis and other life activities when plants do not keep enough water in their cells, they wilt and die stomate: a microscopic hole in a plant leaf which allows gases to enter and leave and water vapor to leave as well. Stomata is the plural of stomate. guard cells: open and close the stomate. the ability of the guard cell to close during periods of limited water availability for the plant allows the plant to maintain water homeostasis

32. Positive Feedback Mechanisms Positive feedback is where the response is the same as the stimulus. In positive feedback the response can be magnified.

33. A good example of positive feedback is the feedback you hear from sound systems in concerts. In this example the stimulus (sound going into microphone) is processed to produce a magnified response (sound coming out of the speakers). Sometimes the microphone picks up sound from the speakers and continues to magnify it until it is out of control (the feedback that hurts your ears). Example in Humans: Oxytocin & Child Labor Positive Feedback Mechanisms

34. The release of oxytocin to intensify the contractions that take place during childbirth. [ [ Positive Feedback in the Human Body In positive feedback the response can be magnified.

35. Name 2 systems that work together.  Circulatory – respiratory  Skeletal – muscular  Digestive – circulatory  Nervous – muscular  Integumentary – circulatory  Endocrine – circulatory  Excretory - circulatory How do they work together? ……. You will investigate through your project & presentation!!