1. Hank Wagner Conference Center Jewish Hospital & St. Mary’s HealthCare 200 Abraham Flexner Way Tuesday, March 12, 2013 8:00 AM – 2:00 PM Dynamics of Ligands & Receptors in Metabolic Regulation The Institute for Molecular Diversity & Drug Design 15 th Annual Symposium 2013 Institute for Molecular Diversity & Drug Design Faculty: Paula J. Bates, Associate Professor of Medicine, Brown Cancer Center Levi J. Beverly, Assistant Professor of Medicine, Brown Cancer Center Douglas Borchman, Professor of Ophthalmology Robert M. Buchanan, Professor of Chemistry Alan Cheng, Assistant Professor of Biochemistry & Molecular Biology Albert R. Cunningham, Associate Professor of Medicine, Brown Cancer Center Douglas S. Darling, Professor of Oral Health & Rehabilitation Teresa W. Fan, Professor of Chemistry Gabino Rafael Fernandez-Botran, Associate Professor of Pathology Gerald B. Hammond, Professor of Chemistry Chuan Hu, Assistant Professor of Biochemistry & Molecular Biology Saeed A. Jortani, Associate Professor of Pathology Sham S. Kakar, Professor of Physiology & Biophysics, Brown Cancer Center Kyung A. Kang, Professor of Chemical Engineering Muriel C. Maurer, Professor of Chemistry Donald M. Miller, Director, J. Graham Brown Cancer Center Eugene G. Mueller, Professor of Chemistry Michael H. Nantz, Professor of Chemistry George R. Pack, Professor and Chairman of Chemistry William M. Pierce, Professor of Pharmacology & Toxicology John F. Richardson, Professor of Chemistry David J. Samuelson, Assistant Professor of Biochemistry & Molecular Biology K. Grant Taylor, Professor Emeritus of Chemistry John O. Trent, Associate Professor of Medicine, Brown Cancer Center Roland Valdes, Jr., Professor of Pathology & Laboratory Medicine James L. Wittliff, Professor of Biochemistry, Brown Cancer Center M. Cecilia Yappert, Professor of Chemistry Xiang Zhang, Associate Professor of Chemistry Special Thanks: Ruth Brinkley FACHE, President & CEO KentuckyOne Health Bill Blair, Hank Wagner Conference Center Bonnie Harvey, Hank Wagner Conference Center Mitzie Wittliff, Hormone Receptor Laboratory Sponsors: Jewish Hospital & St. Mary’s Healthcare Peptides International, Inc. UofL College of Arts & Sciences UofL Hormone Receptor Laboratory UofL Office of the Vice President for Research UofL School of Medicine Symposium Organizing Committee: James L. Wittliff, Chair Douglas Borchman Jackie Spatola Sarah A. Andres Poster Judging Committee: Rafael Fernandez-Botran, Chair Alan Cheng Paula J. Bates Muriel C. Maurer Douglas S. Darling

2. The Institute for Molecular Diversity & Drug Design (IMD 3 ) 15th Annual Symposium Dynamics of Ligands & Receptors in Metabolic Regulation Hank Wagner Conference Center at Jewish Hospital & St. Mary’s Healthcare Thomas Burris – Widely regarded investigator from The Scripps Research Institute, Tom graduated in chemistry magna cum laude, Southern Illinois University and received a Ph. D. degree in molecular biophysics, Florida State University. He then studied molecular endocrinology with Bert O’Malley at Baylor College of Medicine and molecular genetics with Ed McCabe at UCLA. His focus on nuclear receptor pharmacology, begun in the O’Malley lab, exploited this field with his innovative approaches. After a decade of drug discovery targeting nuclear receptors at Johnson & Johnson and Eli Lilly & Co, Tom returned to academia as Professor & Head, Nuclear Receptor Biol. Lab, Pennington Res Ctr, LSU in 2006 joining Scripps in 2008. He is a prolific scientist with frequent novel papers in Nature, Cell, ACS Chemical Biology & PNAS while serving on editorial boards for Molecular Pharmacology, JBC as well as for Molecular Endocrinology. Tomas Ganz – Professor of Medicine & Pathology at UCLA, Tom received a B.S. degree in Physics & M.D. at UCLA with a Ph. D. from Cal Tech. After a residency in Medicine at UCLA, he studied with Harvey Herschman. Tom’s major focus is the biological role of peptide mediators in innate immunity & iron metabolism. His inventive studies of the pathogenesis of anemia of inflammation and iron overload states, and the development of hepcidin agonists and antagonists are globally recognized. Tom has published > 250 articles & 30 chapters and served as Assoc. Editor of Blood, President, Intl Bioiron Soc and member of NIH Study Sections. Co-founder of Intrinsic LifeSciences & Merganser Biotech, focused on diagnostic and therapeutic applications of hepcidin, Tom received the Marcel Simon Award of the International Bioiron Society for the discovery of hepcidin. Distinguished Visiting Speakers: Michael Pennington – Current President & CEO of Peptides International, Mike received a Ph. D., University of Florida, then joined Schering-Plough in 1988. In late 1989, he joined Bachem Bioscience and rapidly rose to President and COO. There Tom built and directed an internationally recognized peptide chemistry team focused on complex peptides and toxins. He publishes articles frequently and collaborates extensively while maintaining an extramurally funded research program. Tom holds many patents and is a founder of Airmid, Inc, a biotech firm advancing his discoveries for autoimmune diseases. He is also an editor of Intl J Peptide Research & Therapeutics and Current Peptide and Protein Letters. Sham Kakar – Well respected investigator of peptide hormone-receptor protein interactions, Sham received a Ph.D. in Biochemistry in Karnal, India & post- doctoral training at Baylor College of Medicine. After faculty appointments at UAB, he joined UofL where he is also in the Brown Cancer Center, CGeMM & IMD3. Sham’s group is recognized for cloning key genes and demonstrating their role in cancer. His research includes targeted therapy using nanotechnology to treat cancer and plasma metabolites to identify biomarkers for diagnosis. He launched a biotech company, Nanomark Therapeutics, to develop his ideas of targeted therapeutics and is Editor-in-Chief of the Journal of Ovarian Research. Featured Speakers: 8:00 amPoster Setup & Continental Breakfast 8:50 am Welcome: James L. Wittliff, Director IMD 3 Chair: Douglas Borchman, Professor of Ophthalmology Chair: Douglas Borchman, Professor of Ophthalmology 9:15 amREV-ERB, a Nuclear Receptor for Heme Thomas P. Burris, Professor of Molecular Therapeutics, The Scripps Research Institute 10:05 am Development of Novel Combination Therapies for Cancer Sham S. Kakar, Professor of Physiology & Biophysics University of Louisville 10:30 am Break & Poster Viewing Chair: George R. Pack, Associate VP for Research Chair: George R. Pack, Associate VP for Research 11:10 am Advancing ShK Peptide Toxins as Therapeutics for Autoimmune Diseases Michael W. Pennington, President & CEO of Peptides International 11:35 pm The Liver: An Endocrine Gland & Target of Regulation Tomas Ganz, Professor of Medicine & Pathology UCLA School of Medicine 12:25 pm Closing Remarks & Poster Awards Rafael Fernandez-Botran, Jackie Spatola & Jim Wittliff 12:30 pm Reception & Poster Viewing Contact Dr. Sarah Andres (sarah.andres@louisville.edu) to register (no fee required).