1. Expediting Precision Medicine Initiatives for Clinical Genomics and Pharma through the Use of Knowledge Automation and Analytics Presenters: Dr. Scott Kahn, Chief Strategy Advisor, Optra Health Dr. Ashwin Kotwaliwale, Product Manager, Optra Health Sponsored by

2. Presenters Dr. Scott Kahn PhD, Chief Strategy Advisor, Optra Health Dr. Kahn most recently served as VP for Illumina's Enterprise Informatics group and Chief Information Officer, leading all scientific software, bioinformatics, and IT initiatives. He was also an Assistant Professor of Chemistry at the University of Urbana-Champaign. Dr. Ashwin Kotwaliwale MD, PhD, Product Manager, Optra Health Dr. Kotwaliwale has over 15 years experience in biomedical informatics. Trained as a medical doctor and then transitioned into bioinformatics. Dr. Kotwaliwale is involved in technology and domain initiatives at Optra Health developing business requirements and innovative solutions. © Copyright 2016 2

3. 3 o Founded in 2007 o Headquartered in Sunnyvale, CA o Digital Healthcare Focus: Knowledge Automation, BioNLP, Machine-learning and Big Data Analytics, Life Sciences Informatics, Medical Device Product and Software Development, Lab Automation o Team: >100 developers including Software, Domain and Product Engineering o Clients: North America, Europe, Asia o Certifications: ISO 9001:2008, ISO 27001 About Optra Health © Copyright 2016

4. Precision Medicine is a Destination  The current state is often beyond digitization of the medical record and the adoption of genomic technologies  How is data accessible for analysis?  Curation and harmonization  Availability of outcomes data  Challenges with data sharing  Once clinical and genomic and outcomes data is aggregated the initial steps to Precision Medicine are enabled © Copyright 2016 4

5. Genomic Medicine Adoption Challenges  Ease of sequencing (NGS) belies the challenge of clinical interpretation  General lack of comprehensive (and error-free) knowledge base(s)  Need for expert bioinformaticians to explore and analyze relevant evidence from disparate sources  Need for review of information within the context of prior interpretations © Copyright 2016 5

6. Introducing the iPhronesis TM Platform  Optra Health has invested in technologies that are exposed as platform services  Natural language processing has been extended to understand genomics in unstructured data  Preconfigured connections to disparate data sources simplify data access (for the bioinformatician)  Knowledge automation enabled through deep machine learning capabilities  Optra Health can extend these services with its 100+ development staff, and seeks to partner with solution providers  Initial focus on bioinformatician (in demo) is being broadened to address needs of variant curator/interpreter and the lab director © Copyright 2016 6

7. Demonstration Overview  Once the data is aggregated, bottlenecks can be overcome allowing for initial Precision Medicine efforts to take shape  Standardization / harmonization activities can be applied in a facile manner  Moving beyond manual curation to extract useful knowledge from text and access phenotypic and clinical information, will be critical to realizing Precision Medicine outcomes  Leveraging a modular platform approach provides easy access to all data forms  Pre-configured reports included, and can be modified per user specs © Copyright 2016 7

8. Summary of iPhronesis Fully-automated informatics is a journey… but Optra Health offers:  An interface to integrate disparate, unstructured data for relationship understanding in an automated fashion  Knowledgebase Creation  Integration to proprietary databases  Visualization, Workflow and Reporting modules  >100 developers available to customize platform to client needs  Partnership business model in place; platform can accelerate solution creation by others © Copyright 2016 8

9. Thank you for joining us! Q & A © Copyright 2016 Optra Health 530 Lakeside Drive Sunnyvale, CA 94085 USA +1-408-524-5300 info@optrahealth.com www.optrahealth.com 9