Download presentation
Presentation is loading. Please wait.
Published bySydney Craig Modified over 8 years ago
1
Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH by Frédéric Coin, Etienne Bergmann, Alexandre Tremeau ‐ Bravard, and Jean ‐ Marc Egly EMBO J. Volume 18(5):1357-1366 March 1, 1999 ©1999 by European Molecular Biology Organization
2
Immunopurification of TFIIH using Ab ‐ p44. Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
3
Transcription and DNA repair activities of TFIIH(ip). Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
4
Composition and enzymatic activities of TFIIH isolated from HD2 cells containing a mutation in the XPD gene. Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
5
Composition and enzymatic activities of TFIIHs from patients with spinal muscular atrophy type I or II. TFIIH complexes isolated from patients with type I or II spinal muscular atrophy [IIH ‐ p44c and IIH ‐ p44(c+t), respectively] were immunopurifed and analyze... Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
6
Mutations in the XPB subunit differentially impede TFIIH transcription activity. Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
7
Artificial DNA promoter opening abolishes the transcription inhibition due to TFIIH of XPB patient. Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
8
XPB mutations prevent promoter opening. Frédéric Coin et al. EMBO J. 1999;18:1357-1366 ©1999 by European Molecular Biology Organization
Similar presentations
© 2025 SlidePlayer.com. Inc.
All rights reserved.