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Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency by Pierre Mangin, Cindy L. Yap, Christelle Nonne, Sharelle A. Sturgeon,

Published byRoberta Walsh Modified over 8 years ago

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Presentation on theme: "Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency by Pierre Mangin, Cindy L. Yap, Christelle Nonne, Sharelle A. Sturgeon,"— Presentation transcript:

1 Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRγ deficiency by Pierre Mangin, Cindy L. Yap, Christelle Nonne, Sharelle A. Sturgeon, Isaac Goncalves, Yuping Yuan, Simone M. Schoenwaelder, Christine E. Wright, Francois Lanza, and Shaun P. Jackson Blood Volume 107(11):4346-4353 June 1, 2006 ©2006 by American Society of Hematology

2 Effect of FcRγ deficiency on occlusive thrombus formation in a “Folts-type” arterial thrombosis model. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

3 Effect of FcRγ deficiency and integrin αIIbβ3 and P2Y12 inhibition on occlusive arterial thrombus formation following electrolytic injury. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

4 Effect of FcRγ deficiency on thrombus formation in a laser-induced arterial thrombosis model. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

5 Spreading and calcium flux of FcRγ–/– mouse platelets on a collagen matrix. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

6 Effect of FcRγ deficiency on platelet tethering, stable adhesion, and thrombus formation on a collagen substrate. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

7 Effect of hirudin on laser-induced thrombus formation in wild-type and FcRγ-deficient mice. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

8 Effect of hirudin on the tail bleeding time of wild-type and FcRγ-deficient mice. Pierre Mangin et al. Blood 2006;107:4346-4353 ©2006 by American Society of Hematology

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