1. DAVE GANGEMI, PH.D. Senior Biomedical Advisor Retired Army Scientist (USAMRIID, Walter Reed Army Institute for Research, Health Affairs, AFRI, and Uniform Services Medical University) Professor Emeritus Clemson University and University of SC School Medicine Microbiology and Molecular Medicine

2. RESEARCH INTEREST Infectious Diseases -Innate Immunity -Antivirals and Immune Modulators -Influenza, Filo- and Flavi-viruses -Virus-Like Particles Systems Application -Hollow Fiber Bioreactors

3. IMPORTANT CONSIDERATIONS FOR DOD GRANT APPLICATIONS Search for grant opportunities utilizing FedBizOpps and grants.gov websites; see also: Identify agency or program with open solicitations (BAAs) and specific topic areas matching your capabilities and technical readiness level (e.g. DTRA, DARPA, BARDA, CDMRP) Identify appropriate funding opportunities: 6.1 – Basic Research 6.2 – Applied Research 6.3 – Advanced Development Guide to FY2016 Research Funding at the Department of Defense (DOD) Contact: James Murday, DC Office of Research Advancement 202-824-5863, Murday@usc.edu

4. Technology Readiness Levels

5. IMPORTANT CONSIDERATIONS FOR DOD GRANT APPLICATIONS Review agency’s application process and forms (program manager contact, preproposal, white paper) Assess the likely competition Identify multiple versus single awards Determine funding level

6. IMPORTANT CONSIDERATIONS FOR DOD GRANT APPLICATIONS Obtain examples of funded DOD grants Practice the “art” of writing white papers and preproposals Know how to prepare a Quad-Chart with precise milestones and a realistic budget Know how to implement Cooperative Research and Development Agreements (CRADAs)

8. What is a Cooperative R&D Agreement (CRADA) Description A Cooperative Research and Development Agreement(CRADA) is a written agreement between one or more federal laboratories and one or more non-federal parties under which the government, through its laboratories, provides personnel, facilities, equipment or other resources with or without reimbursement (but not funds to non-federal parties). The non-federal parties provide personnel, funds, services, facilities, equipment or other resources to conduct specific research or development efforts that are consistent with the mission of the laboratory. When a CRADA is Appropriate CRADAs provide an easy way to collaborate with ARL. CRADAs allow ARL researchers to exchange technical expertise with non-federal partners, and to accept reimbursement for research conducted under the CRADA. CRADAs also protect a researcher's rights and those of ARL to inventions the researcher may make. CRADAs are appropriate when ideas, staff, materials, and equipment are to be exchanged over a period of time for the purpose of collaboration and/or an invention may result. Funds may be provided to ARL under a CRADA.

9. THE IMPORTANCE OF A CRADA “Foot-in-the-door” for DOD applications Establishes a formal relationship with DOD scientists Documents DOD’s interest in your research capabilities and your credibility Often encourages DOD PI to support grant applications or even contribute as co-investigators

10. A COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT Between Asylia Biosciences Inc. Bryan, Texas 77807 (Cooperator) and US Army Medical Research Institute of Infectious Diseases (USAMRIID) Fort Detrick, Maryland 21702-5011 (Laboratory) Article 1. Background 1.00 This Agreement is entered into under the authority of the Federal Technology Transfer Act of 1986, 15 U.S.C. 3710a, et seq., between the Cooperator and the Laboratory, the parties to this Agreement. 1.01 Laboratory, on behalf of the U.S. Government, and Cooperator desire to cooperate in research and development on Hollow Fiber Systems for Large-Scale Production of Monoclonal Antibodies, Virus-like Particles, and Virus Replicons according to the attached Statement of Work (SOW) described in Appendix A. NOW, THEREFORE, the parties agree as follows:

16. CONCLUDING COMMENTS Focus on technical strengths clearly identifying specific aims and milestones Know your competition Write to target the interest of funding agency (e.g. DTRA, DARPA, CDMRP, BARDA) Establish collaborative interactions before submitting

17. CONCLUDING COMMENTS Utilize ADI’s Expertise and Capabilities to Help Guide You Through the Grant Process