1. 1-Herpesviruses VirusPrimary InfectionUsual Site of Latency Recurrent InfectionRoute of Transmission HSV-1Gingivostomatitis Vesicular lesions above the waist Cranial sensory ganglia Herpes labialis, encephalitis, keratitis Via respiratory secretions, direct contact with virus vesicle & saliva HSV-2 Herpes genitalis Vesicular lesions below the waist Perinatal disseminated disease Lumbar or sacral sensory ganglia Herpes genitalisSexual contact, perinatal infection VZVVaricella Initial infection in oropharynx. It spreads via blood to liver then to skin. Cranial or thoracic sensory ganglia Zoster reactivate years later, in older and immuno- compromised individuals. Via respiratory secretions Both varicella vaccine & zoster vaccine contain live, attenuated varicella-zoster virus. Immunocompromised patients exposed to the virus should receive: Passive immunization with varicella- zoster immune globulin & Acyclovir to prevent disseminated

2. VirusPrimary InfectionUsual Site of Latency Recurrent InfectionRoute of Transmission EBV Infectious mononucleosis It start in pharyngeal epithelium, spreads to cervical lymph nodes, then travels via blood to liver & spleen. B lymphocytesNoneVia respiratory secretions & saliva CMV Congenital infection (in utero) Mononucleosis in transfusion recipients. Pneumonia & hepatitis in immuno-compromised patients Retinitis & enteritis, in AIDS patients Uncertain Initial infection in oropharynx. In fetus, virus spreads to CNS & kidneys. Adults lymphocytes are involved. Asymptomatic shedding Dissemination in immuno- compromised patients can be primary infection or reactivation of latent infection Intrauterine infection transfusions, sexual contact, via secretions (blood, saliva, semen, cervical mucus, breast milk & urine) HHV-8Uncertain Kaposi's sarcoma in AIDS patients Sexual or organ transplantation 1-Herpesviruses

3. Herpes viruses-1 A herpetic whitlow in a dentist caused by herpes simplex virus

4. 1-Herpesviruses Varicella viruses

5. 1-Herpesviruses Zoster viruses

6. 1-Herpesviruses Epstein-Barr virus