1. Sjogren’s Syndrome Jaya Marie Millan MLS 3C

2. What is sjogren’s syndrome? Sjogren's syndrome is a chronic autoimmune disease in which a person’s white blood cells attack their moisture- producing glands (lachrymal glands and salivary glands.)

3. Cause/ Etiology Genetic predisposition, hormonal, and environmental factors patient's immune system attacks healthy cells and tissues, mistaking them for dangerous pathogens, such as infectious bacteria or viruses. lymphocytic infiltrates of lachrymal and salivary glands. destruction of the salivary and lachrymal glands

4. Characteristics

5. HLA asso: (HLA)-DR and HLA-DQ gene regions Age group asso & sex group asso: Women Can also affect men and children Middle age women (between 35-35 y.o.)

6. Laboratory diagnosis Rose Bengal test The Schirmer test Blood tests Urine sample

7. References: Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American–European Consensus Group. Ann Rheum Dis. 2002;61:554–8. Jonsson R, Bowman SJ, Gordon TP. Sjögren’s syndrome. In: Koopman WJ, editor. Arthritis and allied conditions. 15th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. pp. 1681–705. Delaleu N, Jonsson R, Koller MM. Sjögren’s syndrome. Eur J Oral Sci. 2005;113:101–13