1. #MOPDB0101
More and earlier cardiovascular events (CVE) and shorter overall survival (OS) in HIV-positive patients (HIV+) compared to the general population differ by sex
Stefan Esser1, Marina Arendt2, Robert Jablonka1, Christina Schulze1, Volker Holzendorf3,
Norbert H. Brockmeyer4, Karl-Heinz Jöckel2, Raimund Erbel2, Nico Reinsch5
on behalf of HIV HEART Study Group and Heinz Nixdorf Recall Investigative Group
1 Clinic of Dermatology, Department of Venereology, University Hospital Essen, Essen, Germany 2 Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, Germany
3 Clinical Trial Centre Leipzig - Coordination Centre for Clinical Trials (ZKS Leipzig - KKS), University Leipzig, Germany 4 Germany Clinic of Dermatology, Center for Sexuell Health and Medizin Ruhruniversity Bochum, Bochum, Germany
5 Department of Internal Medicine I and Cardiology, Devision of Electrophysiology, Alfried Krupp Hospital, Essen, Germany

2. Conflict of Interest Research Grant: Scientific council:
BMS, Gilead, GSK, Janssen, MSD, ViiV
Scientific council:
AbbVie, BMS, Gilead, Janssen, MSD, ViiV
Honorary lecturer:
Financial participation in the course of a business: NONE
Seminars and conferences:

3. Background
The OS of HIV+ should be adapted to the general population by antiretroviral treatment.
But in the aging HIV+ CVE and strokes became more frequent.
Methods
We compare CVE, stroke and OS of HIV+ outpatients of the HIV HEART study (HIVH) and of HIV-negative controls of the population-based Heinz Nixdorf Recall study (HNR), both recruited from the German Ruhr area
HIVH cases with HNR controls are matched in a 1:2 ratio by sex and age.
CVE are defined by myocardial infarction and sudden cardiac death. Stroke is defined as both ischemic and haemorrhagic stroke.
Cox proportional hazard models are used to investigate the impact of study affiliation on OS, CVE and stroke with time from study start to event or last contact.
In Kaplan Meier curves we display the OS survival and the disease-free survival regarding CVE stratified by HIV status and sex, respectively.

4. Results
HNR: Heinz Nixdorf Recall Study = HNR = General population; HIV HEART Study = HIVH = HIV+ patients
Model 0 is the crude model showing the HR for being HIV+ compared to be HIV-.
Model 1 is adjusted for age, active smoking and for men additionally for diabetes.

5. Results & Conclusions Mean Follow-up time HNR: 7.6 y, HIVH 4.8 y OS
CVE
HIV+ males had increased incidence of CVE.
HIV+ males had a higher mortality rate and get CVE at younger age than general population.