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Apomorphine pump in advanced Parkinson's disease: Effects on motor and nonmotor symptoms with brain metabolism correlations  Manon Auffret, Florence Le.

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Presentation on theme: "Apomorphine pump in advanced Parkinson's disease: Effects on motor and nonmotor symptoms with brain metabolism correlations  Manon Auffret, Florence Le."— Presentation transcript:

1 Apomorphine pump in advanced Parkinson's disease: Effects on motor and nonmotor symptoms with brain metabolism correlations  Manon Auffret, Florence Le Jeune, Anne Maurus, Sophie Drapier, Jean-François Houvenaghel, Gabriel Hadrien Robert, Paul Sauleau, Marc Vérin  Journal of the Neurological Sciences  Volume 372, Pages (January 2017) DOI: /j.jns Copyright © 2016 Elsevier B.V. Terms and Conditions

2 Fig. 1 Changes in brain glucose metabolism after six months of apomorphine pump (M6) in patients with advanced Parkinson's disease (n=12, p<0.001 and K>50). A: increase in brain glucose metabolism at M6, B: decrease in brain glucose metabolism at M6. Abbreviations: x, y, z=Talairach coordinates of the regions. BA=Brodmann area. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2016 Elsevier B.V. Terms and Conditions

3 Fig. 2 Correlations between significant clinical scores and changes in brain glucose metabolism after six months of apomorphine pump (M6) in patients with advanced Parkinson's disease (p<0.001 and K>50). A: positive correlation between WCST and metabolism; B: negative correlation between WCST and metabolism; C: negative correlation between LARS-i and metabolism; D: positive correlation between Schwab and England “on” score and metabolism; E: negative correlation between Schwab and England “on” score and metabolism. Abbreviations: WCST=Wisconsin Card sorting test; LARS-I=Lille Apathy rating Scale, informant-based version; S&E: Schwab & England. Journal of the Neurological Sciences  , DOI: ( /j.jns ) Copyright © 2016 Elsevier B.V. Terms and Conditions

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