1. Prof. Chris Rayner and Dr. Xiaojun Lai
iPRD Training
Prof. Chris Rayner and Dr. Xiaojun Lai
MSc in Chemical Process Research and Development

2. MSc in Chemical Process Research and Development
iPRD Training
MSc in Chemical Process Research and Development
To train chemists and chemical engineers for a career in Process Chemistry
Joint Chemistry/Chemical Engineering activity
Target average intake 15 students p/a
Key module is design project (an in depth analysis of a specific fine chemical across its lifecycle)
Laboratory or computational based 3rd semester project

3. MSc in Chemical Process Research and Development
iPRD Training
MSc in Chemical Process Research and Development
Chemists and chemical engineers work together to solve problems of relevance to Process Chemistry
Chemists learn advanced Chemistry and fundamental chemical engineering
Chemical engineers learn advanced chemical engineering and fundamental chemistry
May lead to PhD opportunities in Process Chemistry at iPRD
Many of the individual modules also available to PhD students conducting research in relevant area and final year undergraduates

5. MSc Projects 2008-9 iPRD Training
Luke Mitchell Transfer hydrogenation of organic nitrogen functionalities Steve Marsden and John Blacker (with AstraZeneca Ltd.)
Pushpa Radhakrishnan Hydrothermal processing of pharmaceutical waste. Paul T. Williams, Jude Onwudili and Chris Rayner (with GlaxoSmithKline Ltd.).
Rob Benson A Novel, Green and Sustainable Process to High Volume Speciality Chemicals John Blacker, John Atherton and Chris Rayner (with BromChem Ltd.)
Balqais Al-Yahyai Assessment of scale-up issues for industrial implementation of the DyeCat process. Patrick McGowan, Richard Blackburn and Chris Rayner (with DyeCat Ltd.).
Tanmay Godiawala Continuous photochemistry as a viable method for fine chemical manufacture. Chris Rayner, John Blacker and Annette Taylor (with Piramal Healthcare Ltd.).
Mirza Haider A new process for the preparation of polymer encapsulated reagents. Nik Kapur, Mark Wilson, Patrick McGowan and Chris Rayner (with Reaxa Ltd.).
Bruno Falcone Pin Efficient Synthesis of Photocrosslinking Amino Acids for Biological Studies Andrew Wilson and Philip Kocienski (with Pfizer Ltd.)

6. Ideas needed for new projects from industry
iPRD Training
Ideas needed for new projects from industry
Priority given to projects with industrial funding (£1500  pounds) 
Practical training for preparation for project, on use of large scale facilities
Realistic expectation of what students will be able to achieve – are we making the most of their time?
Industrial scholarship allocation
To students with first class degrees, continuation dependent on progress
Further allocation after Semester 1 exams, with stronger link to sponsor, e.g. site visit

7. iPRD Training
Module : Case Studies in Fine Chemical and Pharmaceutical Synthesis Very good feedback from students; run in second semester after completion of introductory material
Industrial lectures;
See summary sheet provided.
* Additional lecture contributions from industry are
invited.

8. IPRD CASE STUDIES MODULE Draft timetable for 2010
26th Jan AstraZeneca Lyn Powell
1. Importance of Impurities in Process Development
2. Low Temperature Reactions from the Laboratory to Large Scale
3. Development of ICI from Laboratory to Launch
2nd Feb Syngenta Patrick Piccione
Batch Reactor Engineering
9th Feb GSK Paul Ravenscroft
Scale-Up in the Pharmaceutical Industry ; Workshop: synthesis of salbutamol
16th Feb ChiralQuest Ian Lennon
Selection of the "Best" Technology for the Manufacture of Single Enantiomer Molecules
Synthesis of Single Enantiomer Molecules - CASE STUDIES
23th Feb Pfizer Charlie Gordon and Julian Smith
Development of a Process for the Manufacture of Amlodipine Besylate
Development of a Process for the Manufacture of Amlodipine Besylate - solving a scale-up problem
2nd Mar Phoenix Lee Proctor
Developing Continuous Processes in the Pharmaceutical and Fine Chemical Industry
Case Study: An Example of a Highly Integrated Multi-Stage Continuous Process for Producing High-Value HIV intermediates using Diazomethane
9th Mar MSD Edward Cleator
Synthesis of a g-Secretase Inhibitor : A Case of Study Process development workshop
16th Mar Shasun Mark Muldowney
An Overview of Taking a project to the plant Process Chemistry: Some Do’s and Don’ts
Process development workshop
20th Apr James Robinson Nigel Corns
An Introduction to Risk Assessment
An Introduction to Laboratory Testing to Evaluate Scale Up Hazards
- Scale-Up to Pilot Plant and Beyond
27th Apr Leeds John Blacker Custom Manufacturing
The Generics Industry
4th May TBA

9. iPRD Training To Rationalise & Integrate with Related MSc Courses
MSc Pharmaceutical Science and Engineering
Fundamental Modules:
Drugs, Processes, Products and People
Process Chemistry and Chemical Technology
Core Modules:
Pharmaceutical Analytical Techniques
Pharmaceutical Product Formulation
Batch Process Engineering
Optional Modules:
Reaction Engineering
Separation Processes
Advances in Chemical Engineering
Organic Synthesis for Fine Chemical and Pharmaceutical Synthesis
Physical Organic Process Chemistry
Case Studies in Fine Chemical and Pharmaceutical Synthesis
Dissertation Research Projects

10. Contacts Prof. Chris Rayner c.m.rayner@leeds.ac.uk Dr Xiaojun Lai