1. HIV/AIDS Implementation Science Research Across NIH: Recent Highlights, Current Priorities, and Partners
Christopher Gordon, PhD
Branch Chief, Division of AIDS Research
National Institute of Mental Health

2. Top Line Messages HIV/AIDS implementation science has been
supported across NIH since prevention and
treatment tools have been available
A wide range of dissemination and implementation
research has been solicited through FOAs from
many ICs.
Partnering with implementing agencies (e.g., CDC,
PEPFAR) has been critical, and continues to expand.
Moving forward, important to triage and target highest
priorities, coordinate efforts, and seek efficiencies

3. Implementation Research: What is it?

4. The Case for Implementation Research in HIV/AIDS
Fauci, A. S., et al. (2013). Nature immunology, 14(11), doi: /ni.2735

5. National Institutes of Health: HIV Implementation Science
Elias Zerhouni, M.D.
Director, NIH
National Institute
on Alcohol Abuse
and Alcoholism
of Arthritis and
Musculoskeletal
and Skin Diseases
National Cancer
Institute
of Diabetes and
Digestive and
Kidney Diseases
of Dental and
Craniofacial
Research
on Drug Abuse
of Environmental
Health Sciences
on Aging
of Child Health
and Human
Development
National Institute on
Deafness and Other
Communication
Disorders
National Eye
National Human
Genome Research
National Heart,
Lung, and Blood
of Mental Health
of Neurological
Disorders and
Stroke
of General
Medical Sciences
of Nursing Research
National Library
of Medicine
Center for
Information
Technology
Scientific Review
National Center
for Complementary
and Alternative
Medicine
of Allergy and
Infectious Diseases
for Research
Resources
Clinical Center
National Center on
Minority Health and
Health Disparities
National Institute of
Biomedical Imaging
and Bioengineering
Fogarty
International
Center

6. A (partial) Timeline for NIH-funded HIV/AIDS Implementation Science
Early 2000s, research funded in dissemination and implementation
science focused on evidence-based prevention interventions
NIMH published a PA in 2006 focused on D&I research in collaboration with the CDC’s DEBI project (Diffusion of Effective Behavioral Intervention)
NIMH standing FOA (revised and updated every three years) that has evolved with the availability of further prevention and treatment advances.
Trans-NIH Implementation Science Workgroup, led by NCI
2009 OAR and Pangaea Global AIDS Foundation Consultation on Implementation Science at IAS, Capetown.
PEPFAR workgroup, led by Melanie Bacon (NIAID), including initiatives in implementation science and most recently, in HOP process
NIH/PEPFAR RFAs and PAs, starting in 2011, NIAID-led.
NIDA/PEPFAR RFA in 2012
NICHD/PEPFAR RFA in 2012 for PMTCT Implementation Science

7. A (partial) Timeline for NIH-funded HIV/AIDS Implementation Science
CFAR, CDC, and Public Health Department collaboration on research efforts to leverage and support the ECHPP efforts ( )
NIMH/NIAID 2013 priority-setting meeting
NIMH 2016 supplements “HIV Pre-exposure Prophylaxis (PrEP) Implementation Science in CDC-funded Public Health Demonstration Projects (Admin Supp)” PA
NIMH standing FOA revised and published in January 2017: “Targeted Implementation Science to Achieve 90/90/90 Goals for HIV/AIDS Prevention and Treatment (R01)”
NIMH Initiatives with PEPFAR for PrEP Implementation Science and Mental Health Screening and Treatment in HIV/AIDS Care Settings

8. Treat All: Policy uptake to full implementation, July 2016
Implementation Science to test models for differentiated care and task-shifting
Implementation of Treat All is just starting.

9. Ambassador Birx: Closing the implementation gap at the Adherence Conference, May 2016
IAPAC Adherence 2017 June 4-6, 2017 • Miami

10. NIMH-funded projects at PEPFAR sites
28 Active Grants
Kenya, Uganda, South Africa, Tanzania, Zambia,
Botswana, Mozambique
Understanding mobility and risk in SEARCH communities
Agricultural Intervention for Food Security and HIV Health Outcomes
Real World Adherence to HIV PrEP in Serodiscorant African Couples
Activating Treatment as Prevention through Community Mobilization
Group Psychotherapy for HIV-Positive Depressed Perinatal Women
Patient-Centered Disclosure Intervention for HIV-Infected Children
Adaptive Strategies for Preventing & Treating Lapses of Retention in Care
CHW's mHealth, and Combination HIV Prevention in a Hotspot

11. HIV Prevention and Care Continuum, Psychosocial Comorbidities, & Translational Research Branch
Chris Gordon Ph.D.
Branch Chief;
HIV Prevention and
Treatment Implementation
Science Program
Mike Stirratt Ph.D.
Adherence to Treatment
and Prevention Program
Greg Greenwood Ph.D.
HIV Testing and Social
Determinants Program
Teri Senn Ph.D.
Psychosocial Co-morbidities
of HIV Prevention and
Treatment Program

12. NIMH Funding Opportunities
FOAs outline and describe the high priority areas for the DAR programs

13. Christopher Gordon, Ph.D.
NIMH Division of AIDS Research Contact Information
Susannah Allison, Ph.D.
Pim Brouwers Ph.D.
Deborah Colosi, Ph.D.
Christopher Gordon, Ph.D.
Gregory Greenwood, Ph.D.
Jeymohan Joseph, Ph.D.
Vasudev R Rao, MBBS, MS.
Dianne Rausch, Ph.D.
Teri Senn, Ph.D.
Michael Stirratt, Ph.D.
David Stoff, Ph.D.
5601 Fishers Lane
Rockville, MD 20852
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THANKS!