Presentation is loading. Please wait.

Presentation is loading. Please wait.

Figure 1. Suppression of pro-inflammatory cytokine secretion on human intestinal epithelial Caco-2 cells CT-P13 and Remicade®. From: Comparable Immune.

Published byZoe Craig Modified over 7 years ago

Similar presentations

Presentation on theme: "Figure 1. Suppression of pro-inflammatory cytokine secretion on human intestinal epithelial Caco-2 cells CT-P13 and Remicade®. From: Comparable Immune."— Presentation transcript:

1 Figure 1. Suppression of pro-inflammatory cytokine secretion on human intestinal epithelial Caco-2 cells CT-P13 and Remicade®. From: Comparable Immune Function Inhibition by the Infliximab Biosimilar CT-P13: Implications for Treatment of Inflammatory Bowel Disease J Crohns Colitis. 2016;11(5): doi: /ecco-jcc/jjw183 J Crohns Colitis | Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please

2 Figure 2. CT-P13 induces cell cytotoxicity and cytokine suppression via tmTNFα-mediated reverse signaling similarly to Remicade® From: Comparable Immune Function Inhibition by the Infliximab Biosimilar CT-P13: Implications for Treatment of Inflammatory Bowel Disease J Crohns Colitis. 2016;11(5): doi: /ecco-jcc/jjw183 J Crohns Colitis | Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please

3 Figure 3. CT-P13 enhances the induction of regulatory macrophages (M regs), which induce wound healing in vitro. (A) CT-P13 inhibits T-cell proliferation in an MLR to the same extent as Remicade®. (B) FACS analysis showing enhanced induction of CD14+CD206+ M regs upon Remsima® or Remicade® treatment. PBMCs from CD patients in an MLR M regs were characterized as double positive (CD14+/CD206+) cell populations of M regs by FACS analysis. (C) Representative pictures of the wound-healing assay. CT-P13 or Remicade® (10 μg/mL) -induced regulatory macrophages or CD14 negative non-regulatory macrophages from CT-P13-induced M reg culture were transferred to either previously scratched or unscratched HCT116 epithelial cells. Images were taken at t = 0 and t = 24 hours. (D) Relative percentage of wound healing observed with the different cell types. Two batches of CT-P13 and Remicade® were used in these assays. From: Comparable Immune Function Inhibition by the Infliximab Biosimilar CT-P13: Implications for Treatment of Inflammatory Bowel Disease J Crohns Colitis. 2016;11(5): doi: /ecco-jcc/jjw183 J Crohns Colitis | Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please

4 Figure 4. Expression levels of tmTNFa on various target cells and ADCC activity of CT-P13 and Remicade® against target cell type. From: Comparable Immune Function Inhibition by the Infliximab Biosimilar CT-P13: Implications for Treatment of Inflammatory Bowel Disease J Crohns Colitis. 2016;11(5): doi: /ecco-jcc/jjw183 J Crohns Colitis | Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please

Download ppt "Figure 1. Suppression of pro-inflammatory cytokine secretion on human intestinal epithelial Caco-2 cells CT-P13 and Remicade®. From: Comparable Immune."

Similar presentations

Opportunistic Bacterial Infections in Inflammatory Bowel Disease By: Christina Philips.

Opportunistic Bacterial Infections in Inflammatory Bowel Disease By: Christina Philips.
The HMG-Co-A reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease Youssef, et. al.

The HMG-Co-A reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease Youssef, et. al.
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation Barrette Kathleen – Dreesen Erwin Asseman.

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation Barrette Kathleen – Dreesen Erwin Asseman.
From: An open day in the metric space

From: An open day in the metric space
Figure 1 WBC count (A), platelet count (B), MPV (C), platelet activation rate (D) and TGF-β1concentration (E) in the PF of women with endometriosis and.

Figure 1 WBC count (A), platelet count (B), MPV (C), platelet activation rate (D) and TGF-β1concentration (E) in the PF of women with endometriosis and.
Figure 2. Quality of life (QOL) scores for functional scale items

Figure 2. Quality of life (QOL) scores for functional scale items
Figure 1. CD11b+CD33+CD14+HLA-DR−/lo myeloid-derived suppressor cell expansion by human immunodeficiency virus.

Figure 1. CD11b+CD33+CD14+HLA-DR−/lo myeloid-derived suppressor cell expansion by human immunodeficiency virus.
Fig. 1 GBM TIMs expand to inhibit vaccine-induced T-cell mediated tumor cytolysis via PD-1/PD-L1 regulatory pathway. (A, D) CD163, DAPI, (B, E) PD-L1,

Fig. 1 GBM TIMs expand to inhibit vaccine-induced T-cell mediated tumor cytolysis via PD-1/PD-L1 regulatory pathway. (A, D) CD163, DAPI, (B, E) PD-L1,
Fig. 1 Increased MIR155HG expression correlates with glioma grade and mesenchymal transition and confers a poor prognosis in GBM patients. (A) The level.

Fig. 1 Increased MIR155HG expression correlates with glioma grade and mesenchymal transition and confers a poor prognosis in GBM patients. (A) The level.
Work disability in inflammatory bowel disease

Work disability in inflammatory bowel disease
Fig. 1. Neem induces caspase-3 activation and cell death in multiple cancer cell types. ( A ) HCT116 cells were treated with neem for 0, 12, 24 and 36h,

Fig. 1. Neem induces caspase-3 activation and cell death in multiple cancer cell types. ( A ) HCT116 cells were treated with neem for 0, 12, 24 and 36h,
Representative flow cytometry dot plots from a healthy individual

Representative flow cytometry dot plots from a healthy individual
Proposed pathogenesis of inflammatory bowel disease and target sites for pharmacological intervention. Shown are the interactions among bacterial antigens.

Proposed pathogenesis of inflammatory bowel disease and target sites for pharmacological intervention. Shown are the interactions among bacterial antigens.
Figure 1. Orthodontic set-up and location of LLLT or placebo-laser

Figure 1. Orthodontic set-up and location of LLLT or placebo-laser
Figure 1 (A) Chest computed tomography scans of the patient

Figure 1 (A) Chest computed tomography scans of the patient
Figure 2. (A) Sézary syndrome patient before treatment

Figure 2. (A) Sézary syndrome patient before treatment
Leigh A. Beamish, Alvaro R. Osornio-Vargas, Eytan Wine 

Leigh A. Beamish, Alvaro R. Osornio-Vargas, Eytan Wine 
Experimental Models of Inflammatory Bowel Diseases

Experimental Models of Inflammatory Bowel Diseases
From: A European Disease

From: A European Disease
Figure 1. Orthodontic set-up and location of LLLT or placebo-laser

Figure 1. Orthodontic set-up and location of LLLT or placebo-laser

Similar presentations

Ads by Google